Asymmetric cross-aldol reactions of α-keto hydrazones and α,β-unsaturated γ-keto hydrazones with trifluoromethyl ketones

Abstract

α-Keto hydrazones and α,β-unsaturated γ-keto hydrazones are suitable pro-nucleophiles for the asymmetric cross-aldol reaction with trifluoromethyl ketones via aza-di(tri)enamine-type intermediates. Quinidine-derived primary amine catalyst affords tertiary trifluoromethylated alcohols in good-to-excellent...

Synthesis, characterization, DFT, antioxidant, antibacterial, pharmacokinetics and inhibition of SARS-CoV-2 main protease of some heterocyclic hydrazones

“…Hydrazone derivatives are considered among the most important molecules in organic chemistry, which show an efficient activity in a wide range of applications including development of new drugs with anti-cancer [1] , [2] , [3] , [4] , antimicrobial [5] , [6] , [7] , analgesic [8] , antihypertensive [9] , anticonvulsant [10] , anti-inflammatory [11] , antituberculosis [ 12 , 13 ], antitumoral [ 14 , 15 ], anti-HIV [ 16 , 17 ], antimalarial [18] , antidepressant [19] , vasodilatory [20] , anti-Alzheimer [ 21 , 22 ], and anti-corrosion activities [ 23 , 24 ]. The presence of both N – N and C=N functional groups in the structure of hydrazones is responsible of their high therapeutic activity [25] .…”