Asymmetric dimethylarginine and gestational diabetes mellitus: a systematic review and meta-analysis

Tiong, Patricia; Kosmider, Logan; Lassi, Zohra S; Arstall, Margaret

doi:10.1007/s12020-022-03260-z

Cited by 4 publications

(4 citation statements)

References 29 publications

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“…Additionally, previous findings of gradual increase in ADMA from first to third trimester [10] and significant lower levels of NOS in women during PTL, compared to women with preterm and term pregnancies that were not in labor, also supports this hypothesis. Furthermore, inhibition of NO synthesis by ADMA may contribute to vascular dysfunction and vasoconstriction which could lead to many other diseases or complications in pregnancy, like preeclampsia [12,24], gestational diabetes [13,25] and isolated intrauterine growth restriction [14]. Higher levels of L-arginine in the preterm group might indicate a compensatory mechanism in response to elevated concentrations of ADMA, to facilitate NO synthesis, since it also requires L-arginine as a substrate [11].…”

Section: Interpretation Of Resultsmentioning

confidence: 99%

“…In normal pregnancy, ADMA levels are low in the first trimester, thus facilitating the NO effect, and gradually increase in the second and third trimester [10]. Higher levels of ADMA have been shown in cardiovascular events [11], in women with preeclampsia [12], gestational diabetes [13] and isolated intrauterine growth restriction [14]. Despite these findings, there is much to be learned about the role of ADMA in pregnancy, pregnancy‐related complications, and during labor.…”

Section: Introductionmentioning

confidence: 99%

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Elevated Plasma Levels of Arginines During Labor Among Women with Spontaneous Preterm Birth: A Prospective Cohort Study

Akhter,

Hedeland,

Bergquist

et al. 2024

American J Rep Immunol

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ProblemPreterm birth (PTB) is a leading cause of infant mortality and morbidity. The pathogenesis of PTB is complex and involves many factors, including socioeconomy, inflammation and infection. Asymmetric dimethylarginine, ADMA and symmetric dimethylarginine, SDMA are involved in labor as inhibitors of nitric oxide, a known relaxant of the uterine smooth muscles. Arginines are scarcely studied in relation to PTB and we aimed to investigate arginines (ADMA, SDMA and L‐arginine) in women with spontaneous PTB and term birth.Methods of the StudyThe study was based on data from the population‐based, prospective cohort BASIC study conducted in Uppsala County, Sweden, between September 2009 and November 2018. Arginines were analyzed by Ultra‐High Performance Liquid Chromatography using plasma samples taken at the onset of labor from women with spontaneous PTB (n = 34) and term birth (n = 45). We also analyzed the inflammation markers CRP, TNF‐R1 and TNF‐R2 and GDF‐15.ResultsWomen with spontaneous PTB had higher plasma levels of ADMA (p < 0.001), and L‐Arginine (p = 0.03). In addition, inflammation marker, TNF‐R1 (p = 0.01) was higher in spontaneous PTB compared to term birth. Further, in spontaneous PTB, no significant correlations could be observed when comparing levels of arginines with inflammation markers, except ADMA versus CRP.ConclusionsThese findings provide novel evidence for the potential involvement of arginines in the pathogenesis of spontaneous PTB and it seems that arginine levels at labor vary independently of several inflammatory markers. Further research is warranted to investigate the potential of arginines as therapeutic targets in the prevention and management of spontaneous PTB.

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Section: Interpretation Of Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Elevated Plasma Levels of Arginines During Labor Among Women with Spontaneous Preterm Birth: A Prospective Cohort Study

Akhter,

Hedeland,

Bergquist

et al. 2024

American J Rep Immunol

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“…Another significant indicator is ADMA. There is growing support for the association of high ADMA levels with conditions such as preeclampsia [42], gestational diabetes [43], IUGR, and placental insufficiency [44]. Furthermore, studies have reported elevated levels of ROS or oxidative stress by-products and decreased antioxidant levels in cases of preterm labor [45].…”

Section: Oxidative Stress During Pregnancymentioning

confidence: 99%

Melatonin Use during Pregnancy and Lactation Complicated by Oxidative Stress: Focus on Offspring’s Cardiovascular–Kidney–Metabolic Health in Animal Models

Tain,

Hsu

2024

Antioxidants

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Cardiovascular–kidney–metabolic (CKM) syndrome has emerged as a major global public health concern, posing a substantial threat to human health. Early-life exposure to oxidative stress may heighten vulnerability to the developmental programming of adult diseases, encompassing various aspects of CKM syndrome. Conversely, the initiation of adverse programming processes can potentially be thwarted through early-life antioxidant interventions. Melatonin, originally recognized for its antioxidant properties, is an endogenous hormone with diverse biological functions. While melatonin has demonstrated benefits in addressing disorders linked to oxidative stress, there has been comparatively less focus on investigating its reprogramming effects on CKM syndrome. This review consolidates the current knowledge on the role of oxidative stress during pregnancy and lactation in inducing CKM traits in offspring, emphasizing the underlying mechanisms. The multifaceted role of melatonin in regulating oxidative stress, mediating fetal programming, and preventing adverse outcomes in offspring positions it as a promising reprogramming strategy. Currently, there is a lack of sufficient information in humans, and the available evidence primarily originates from animal studies. This opens up new avenues for novel preventive intervention in CKM syndrome.

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“…[119] There is no evidence to support an association between maternal smoking during pregnancy and the risk of GDM. [120] Higher consumption of fast food (burgers, sausages and pizza) before pregnancy is an independent risk factor for GDM. [121] Women who reported very fast eating speed, compared with those reporting slow eating speed, were associated with an increased incidence of GDM, which may be largely mediated by increased body fat.…”

Section: Othersmentioning

confidence: 99%

Dietary management of gestational diabetes: A review

Long,

Liang

2024

Medicine

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Gestational diabetes mellitus (GDM) is a common condition in pregnant women that can affect the health of both the mother and the fetus. A healthy diet reduces the risk of GDM, while on the contrary, an unhealthy diet can increase the risk of developing GDM. Dietary interventions remain an important way to control GDM at this time. However, real-life diets are complex and varied, and the effect of these diets on gestational diabetes is unknown. This article summarizes research related to dietary control of GDM. Hopefully, this will help with dietary interventions for people with GDM.

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Asymmetric dimethylarginine and gestational diabetes mellitus: a systematic review and meta-analysis

Cited by 4 publications

References 29 publications

Elevated Plasma Levels of Arginines During Labor Among Women with Spontaneous Preterm Birth: A Prospective Cohort Study

Elevated Plasma Levels of Arginines During Labor Among Women with Spontaneous Preterm Birth: A Prospective Cohort Study

Melatonin Use during Pregnancy and Lactation Complicated by Oxidative Stress: Focus on Offspring’s Cardiovascular–Kidney–Metabolic Health in Animal Models

Dietary management of gestational diabetes: A review

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