Asymmetric dimethylarginine and nitric oxide levels in migraine during the interictal period

Güldiken, Babürhan; Demir, Muzaffer; Güldiken, Sibel; Turgut, Nilda; Özkan, Hülya; Kabayel, Levent; Tuğrul, Armağan

doi:10.1016/j.jocn.2008.08.015

Cited by 27 publications

(20 citation statements)

References 29 publications

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“…Therefore, in our study, ADMA level, a marker of endothelial dysfunction, was measured in migraine cases. To the contrary of two previously conducted studies, ADMA levels were found to be significantly higher in migraine cases compared to the control group in our study [7, 8]. This finding supports the roles of oxidative stress and endothelial dysfunction in migraine pathogenesis.…”

Section: Discussionsupporting

confidence: 54%

“…Asymmetric dimethylarginine (ADMA) is nitric oxide synthase inhibitor and ADMA has close association with endothelial dysfunction and oxidative stress [6]. There is limited number of studies investigating ADMA levels in patients with migraine [7, 8]. No difference has been found in ADMA and NO levels between migraine patients during interictal period and healthy controls in a previous study [7].…”

Section: Introductionmentioning

confidence: 99%

“…There is limited number of studies investigating ADMA levels in patients with migraine [7, 8]. No difference has been found in ADMA and NO levels between migraine patients during interictal period and healthy controls in a previous study [7]. However, ADMA levels had not been investigated in patients with migraine attack.…”

Section: Introductionmentioning

confidence: 99%

“…However, ADMA levels had not been investigated in patients with migraine attack. The association between ADMA and NO in migraine attack is not well-known [7]. For these purposes, in present study, the relationships between migraine, oxidative stress and endothelial dysfunction were investigated by comparing NO and ADMA levels in migraine patients with headache attack and interictal period.…”

Section: Introductionmentioning

confidence: 99%

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Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine

et al. 2011

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Asymmetric dimethylarginine (ADMA) has been found as correlated with endothelial dysfunction and oxidative stress. There are few studies regarding ADMA and nitric oxide (NO) levels in patients with migraine and alterations of ADMA and NO levels during migraine attack are not well-known. Therefore, in present study, we aimed to measure NO and ADMA levels in patients with migraine and compare them with the control group to investigate the correlation between migraine, oxidative stress and endothelial dysfunction. The migraine group consisted of 59 patients, including 22 suffering from migraine with aura and 37 suffering from migraine without aura. The control group consisted of 31 healthy volunteers without headache. The patients in migraine group were divided into subgroups based on whether attack period was present or not and whether it was migraine with or without aura. Plasma ADMA levels were measured using an enzyme-linked immunosorbent assay method. Migraine patients had higher concentrations of NO (35.6 ± 7.7, 31.0 ± 6.2 μmol/L, respectively, p = 0.005) and ADMA (0.409 ± 0.028, 0.381 ± 0.044 μmol/L, respectively, p = 0.001) levels when compared with the healthy controls. During migraine attack, NO and ADMA levels were found to be significantly higher in migraine group as compared to control group (respectively, p = 0.015, p = 0.014). Similarly, NO and ADMA levels in the patients with migraine in the interictal period were found to be significantly higher as compared to control group (p = 0.011, p = 0.003). In conclusion, higher ADMA and NO levels of patients with migraine supported that oxidative stress and endothelial dysfunction may have a role in migraine pathogenesis.

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Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine

et al. 2011

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show abstract

“…Asymmetric dimethylarginine (ADMA) is nitric oxide synthase inhibitor and ADMA has close association with endothelial dysfunction and oxidative stress [6]. There is limited number of studies investigating ADMA levels in patients with migraine [7,8]. No difference has been found in ADMA and NO levels between migraine patients during interictal period and healthy controls in a previous study [7].…”

Section: Introductionmentioning

confidence: 98%

Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine

et al. 2011

View full text Add to dashboard Cite

Asymmetric dimethylarginine (ADMA) has been found as correlated with endothelial dysfunction and oxidative stress. There are few studies regarding ADMA and nitric oxide (NO) levels in patients with migraine and alterations of ADMA and NO levels during migraine attack are not well-known. Therefore, in present study, we aimed to measure NO and ADMA levels in patients with migraine and compare them with the control group to investigate the correlation between migraine, oxidative stress and endothelial dysfunction. The migraine group consisted of 59 patients, including 22 suffering from migraine with aura and 37 suffering from migraine without aura. The control group consisted of 31 healthy volunteers without headache. The patients in migraine group were divided into subgroups based on whether attack period was present or not and whether it was migraine with or without aura. Plasma ADMA levels were measured using an enzyme-linked immunosorbent assay method. Migraine patients had higher concentrations of NO (35.6 ± 7.7, 31.0 ± 6.2 lmol/L, respectively, p = 0.005) and ADMA (0.409 ± 0.028, 0.381 ± 0.044 lmol/L, respectively, p = 0.001) levels when compared with the healthy controls. During migraine attack, NO and ADMA levels were found to be significantly higher in migraine group as compared to control group (respectively, p = 0.015, p = 0.014). Similarly, NO and ADMA levels in the patients with migraine in the interictal period were found to be significantly higher as compared to control group (p = 0.011, p = 0.003). In conclusion, higher ADMA and NO levels of patients with migraine supported that oxidative stress and endothelial dysfunction may have a role in migraine pathogenesis.

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Levels of Asymmetric Dimethylar Ginine and Risk of Neurovascular Diseases: A Systematic Review and Meta‐Analysis

Dai,

Zhang,

Guo

et al. 2024

Molecular Nutrition Food Res

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ScopeThe purpose of this study was to provide clear evidence that reliably quantifies the association of Asymmetric dimethylarginine (ADMA) levels with the risk of neurovascular diseases.Methods and resultsThe Pubmed, Web of Science, and Embase were systematically searched to identify eligible studies published until August 2024. A total of 31 eligible studies were identified. Pooled results indicated that patients with stroke yielded a higher ADMA level than healthy controls [standardized mean difference (SMD) = 1.02, 95% CI = 0.92–1.12, P = 0.001]. Subgroup analyses showed that geographical location, sample type, number of events and the proportion of male participants were statistically significant sources of heterogeneity. Similarly, a significant association with a pooled risk ratio (RR) of 1.60 (95% CI = 1.60–1.91) was shown between ADMA exposure and the risk of stroke from seven cohort studies. There was a statistically significant difference between ADMA level and small vessel disease (SVD) (SMD = 0.33, 95% CI = 0.07–0.58, p = 0.001). In addition, migraine patients tend to have elevated ADMA levels compared to healthy controls (SMD = 0.39, 95% CI = 0.11–0.67, P = 0.001).ConclusionsOur results indicate that ADMA levels have significant effects in patients with stroke, SVD, and migraine.

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Asymmetric dimethylarginine and nitric oxide levels in migraine during the interictal period

Cited by 27 publications

References 29 publications

Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine

Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine

Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine

Levels of Asymmetric Dimethylar Ginine and Risk of Neurovascular Diseases: A Systematic Review and Meta‐Analysis

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