Asymmetric distribution of Modic changes in patients with lumbar disc herniation

Li, Zhaohui; Gao, Xianda; Ding, Wenyuan; Li, Ruoyu; Yang, Sidong

doi:10.1007/s00586-023-07664-x

Cited by 3 publications

(2 citation statements)

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“…Clinical and imaging factors were also examined in the present meta-analysis. Modic changes typically include reactive vertebral changes associated with inflammation, an unstable microenvironment or degenerative disc disease ( 39 , 40 ). As the intervertebral disc itself does not contain vascular tissue, the micropores in the endplate are exchange channels for nutrients, water and other metabolic products.…”

Section: Discussionmentioning

confidence: 99%

“…As the intervertebral disc itself does not contain vascular tissue, the micropores in the endplate are exchange channels for nutrients, water and other metabolic products. When the endplate changes, its nutritional effect on the intervertebral disc decreases ( 39 , 40 ). Therefore, it is not difficult to understand that modic changes are associated with a higher risk of rLDH.…”

Section: Discussionmentioning

confidence: 99%

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Associations of recurrent lumbar disc herniation after percutaneous endoscopic lumbar discectomy with age, body mass index, modic change, disc degeneration and sacral slope: A quantitative review

Zhao,

Zeng,

Zhao

et al. 2024

Exp Ther Med

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Recurrent lumbar disc herniation (rLDH) seriously affects the quality of life of patients and increases the medical burden. The purpose of the present study was to determine the risk factors for rLDH after percutaneous endoscopic lumbar discectomy (PELD). The PubMed, Cochrane Library and Embase databases were searched for studies on the factors associated with rLDH after PELD. The databases were searched from inception to March 30, 2023. The combined effects of categorical variables and continuous variables were measured using odds ratios (ORs) and weighted mean differences (WMDs), respectively, and their corresponding 95% confidence intervals (CIs) were calculated. RevMan 5.3 software was used for data analysis. A total of 9 case-control studies were included in this meta-analysis, comprising 5,446 patients. This study explored a total of 18 potential risk factors for rLDH after PELD; ultimately, 5 factors were associated with the risk of rLDH. Meta-analysis showed that older age (WMD=6.49, 95% CI: 2.52 to 10.46), greater body mass index (WMD=1.16, 95% CI: 0.69 to 1.62), modic change (OR=2.48, 95% CI: 1.54 to 3.99), Pfirrmann grade ≥4 (OR=2.84, 95% CI: 1.3 to 6.16) and greater sacral slope angle (WMD=3.48, 95% CI: 0.53 to 6.42) were risk factors for rLDH after PELD. The risk factors identified in the present study may enable clinicians to identify high-risk populations early and to select appropriate surgical procedures to reduce the risk of rLDH. Perioperative interventions targeting the modifiable factors identified in this study may be beneficial for reducing the risk of rLDH.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%