2024
DOI: 10.1021/acs.orglett.4c00312
|View full text |Cite
|
Sign up to set email alerts
|

Asymmetric Fluorocyclization of Difluoroalkenes with Concomitant Formation of a Trifluoromethyl Group

Chino Igarashi,
Tomoya Mayumi,
Hiromichi Egami
et al.

Abstract: Asymmetric electrophilic fluorination of difluoroalkenes remains undeveloped because of the poor reactivity of difluoroalkenes with electrophiles. However, such reactions, if feasible, are expected to be useful for the synthesis of chiral heterocyclic compounds with a trifluoromethyl group at the stereogenic center. In this Letter, we disclose the first example of asymmetric fluoroamide cyclization of difluoroalkenes using our dianionic phase-transfer catalyst. This reaction provides unique chiral trifluoromet… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 51 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?