Asymmetric gold catalysis enabled by specially designed ligands

Abstract

Over the past two decades, gold catalysis has witnessed a remarkable surge fueling the advent of enantioselective gold catalysis. Based on the oxidation states of the gold complex involved in...

Unlocking the potential of water-soluble gold(i)–NHC complexes: unveiling the role of carboxylic acid in cycloisomerization of alkynyl amino acid derivatives

“…13 However, the discovery of gold's ability to activate C–C unsaturated groups to promote the addition of a variety of nucleophiles to these multiple bonds, 14,15 together with gold catalysts tolerance to a wide range of functional groups and mild reaction conditions, 16–18 has made gold-based complexes highly sought after. 19 These characteristics have led to an exponential growth of homogeneous gold catalysis in the last twenty years and paved the way for the development of numerous of new catalytic transformations, including tandem reactions and asymmetric catalysis using gold, 20–22 turning it into a powerful tool in mainstream organic chemistry.…”

β-Cyclodextrin–NHC–Au(I)-Catalyzed Enantioconvergent 1,5-Enyne Cycloisomerizations

“…Those have for instance included triethynylphosphine ligands bearing bulky ends as well as the more recent variants consisting of bulky tris­( o -biaryl)­phosphine ligands, NHC-capped cyclodextrins (CDs), and resorcin[4]­arene-based cavitands . Naturally, confined catalysis is suited to enantioselective catalysis, which is obviously easier to achieve if the host is intrinsically chiral . In this context, we have been interested over the past decade in the development of NHC–Au­(I) complexes attached to α-, β-, or γ-CD that could serve as chiral nanoreactors .…”