Asymmetric Hybrid Silica Nanomotors for Capture and Cargo Transport: Towards a Novel Motion‐Based DNA Sensor

Simmchen, Juliane; Baeza, Alejandro; Ruiz, D. E.; Esplandiu, M.J.; Vallet‐Regí, María

doi:10.1002/smll.201101593

Cited by 91 publications

(88 citation statements)

References 47 publications

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“…Besides tubular micromotors, which can generate bubbles through one-dimensional confinement, catalase was conjugated onto one side of Janus particles, as well. With a rough surface (Figure 4C(b)) 57 or a relatively large size (>10 μm) (Figure 4C(c)) 72,73 at the biocatalytic face, oxygen bubbles could generate quickly and push the motors toward the non-enzyme side. Catalase-based enzymatic motors by a bubble propulsion mechanism can achieve directional movement with extremely high velocity up to hundreds of micrometers per second, more than 10 times higher than the phoretic motion of micromotors such as urea-powered microcapsule motors, but biotoxicity and high oxidative activity of H 2 O 2 fuel limited these motors’ realistic applications, especially in the biomedical field.…”

Section: Enzyme-powered Micro/nanomotorsmentioning

confidence: 99%

Enzyme Catalysis To Power Micro/Nanomachines

et al. 2016

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Enzymes play a crucial role in many biological processes which require harnessing and converting free chemical energy into kinetic forces in order to accomplish tasks. Enzymes are considered to be molecular machines, not only because of their capability of energy conversion in biological systems but also because enzymatic catalysis can result in enhanced diffusion of enzymes at a molecular level. Enlightened by nature’s design of biological machinery, researchers have investigated various types of synthetic micro/nanomachines by using enzymatic reactions to achieve self-propulsion of micro/nanoarchitectures. Yet, the mechanism of motion is still under debate in current literature. Versatile proof-of-concept applications of these enzyme-powered micro/nanodevices have been recently demonstrated. In this review, we focus on discussing enzymes not only as stochastic swimmers but also as nanoengines to power self-propelled synthetic motors. We present an overview on different enzyme-powered micro/nanomachines, the current debate on their motion mechanism, methods to provide motion and speed control, and an outlook of the future potentials of this multidisciplinary field.

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Section: Enzyme-powered Micro/nanomotorsmentioning

confidence: 99%

Enzyme Catalysis To Power Micro/Nanomachines

et al. 2016

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“…Different techniques haven been developed to achieve cargo pickup, such as electrostatic attraction (51), specific or nonspecific binding (51)(52)(53)(54)(55)(56), magnetic interactions (57,58), hydrodynamic interactions (59), hydrophobic affinity (31), molecular imprinting (60), and even purely mechanical force (46,61). Most of these cargo transport systems require the cargo and/or the cargo carrier to be functionalized in some way (31,51,(53)(54)(55)(56)60). Those that do not have such a requirement typically involve the use of magnetic fields to find and manipulate cargo (29,30,33,34).…”

Section: Significancementioning

confidence: 99%

Catalytically powered dynamic assembly of rod-shaped nanomotors and passive tracer particles

Wang

Duan

Sen

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

179

173

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Nano-and microscale motors powered by catalytic reactions exhibit collective behavior such as swarming, predator-prey interactions, and chemotaxis that resemble those of biological microorganisms. A quantitative understanding of the catalytically generated forces between particles that lead to these behaviors has so far been lacking. Observations and numerical simulations of pairwise interactions between gold-platinum nanorods in hydrogen peroxide solutions show that attractive and repulsive interactions arise from the catalytically generated electric field. Electrokinetic effects drive the assembly of staggered doublets and triplets of nanorods that are moving in the same direction. None of these behaviors are observed with nanorods composed of a single metal. The motors also collect tracer microparticles at their head or tail, depending on the charge of the particles, actively assembling them into close-packed rafts and aggregates of rafts. These motor-tracer particle interactions can also be understood in terms of the catalytically generated electric field around the ends of the nanorod motors.dynamic interactions | self-assembly | colloidal transport T he dynamic interactions between moving objects, in particular their response to external stimuli and their communication with each other, govern their collective behavior on many length scales. Schooling of fish and flocking of birds are good examples of emergent phenomena that are orchestrated by communication between individuals in a large group. In these systems, macroscale organization is typically driven by nearest neighbor interactions that follow simple rules. To reach the level of organization seen in such living assemblies, fast and precise (in terms of distances, angles, and velocities) communication and control are required from the members. It is now straightforward to create computational models from which such dynamic structures emerge, but artificial systems that mimic behaviors as complicated as fish schooling have very rarely been realized experimentally in macroscopic engineered systems (1). On the other hand, self-assembly at the nano-and molecular levels already demonstrates a certain level of complexity and has furthered our understanding of dynamic interactions at small scales (2, 3).There are already many examples of particle assembly driven by local forces or externally applied fields. Externally applied light, magnetic, electric, and acoustic fields can drive symmetric particles into ordered arrays (4-7). Colloidal Janus particles selfassemble into complex structures by various mechanisms (8-12). However, in these examples the particle aggregates hardly approach the complexity of assemblies of living organisms; the interactions are passive responses to local forces and external fields with very limited interparticle communication or active response to the behavior of nearest neighbors.Interactions between active particles, on the other hand, can more closely mimic those of living organisms (13-17). Powered particles generate signals, t...

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“…For instance, these microshuttles have been employed for transport and release of drug-loaded nanoparticles [175], capture and transport of cancer cells or nucleic acids [176,177] and finally, quantitative detection of different analytes such as silver ions or specific oligonucleotide sequences [178,179]. In our research group, an innovative self-propelled nanodevice based on Janus mesoporous silica particles able to perform motion, cargo transport, and target recognition has been recently described [180]. These nanoparticiples constitute a very interesting alternative to already existing applications not only by their easy functionalization but also by the possibility to transport molecules trapped within the silica matrix.…”

Section: Mesoporous Motor Particlementioning

confidence: 99%

Mesoporous Silica Nanoparticles: Their Projection in Nanomedicine

Vallet‐Regí

2012

ISRN Materials Science

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Mesoporous silica nanoparticles are receiving growing attention by the scientific biomedical community. Among the different types of inorganic nanomaterials, mesoporous silica nanoparticles have emerged as promising multifunctional platforms for nanomedicine. Since their introduction in the drug delivery landscape in 2001, mesoporous materials for drug delivery are receiving growing scientific interest for their potential applications in the biotechnology and nanomedicine fields. The ceramic matrix efficiently protects entrapped guest molecules against enzymatic degradation or denaturation induced by pH and temperature as no swelling or porosity changes take place as a response to variations in the surrounding medium. It is possible to load huge amounts of cargo into the mesopore voids and capping the pore entrances with different nanogates. The application of a stimulus provokes the nanocap removal and triggers the departure of the cargo. This strategy permits the design of stimuliresponsive drug delivery nanodevices.

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Asymmetric Hybrid Silica Nanomotors for Capture and Cargo Transport: Towards a Novel Motion‐Based DNA Sensor

Cited by 91 publications

References 47 publications

Enzyme Catalysis To Power Micro/Nanomachines

Enzyme Catalysis To Power Micro/Nanomachines

Catalytically powered dynamic assembly of rod-shaped nanomotors and passive tracer particles

Mesoporous Silica Nanoparticles: Their Projection in Nanomedicine

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