Asymmetric Hydrogenation in Continuous‐Flow Conditions

Enantioselective and Step-Economic Synthesis of the Chiral Amine Fragment in the Tyrosine Kinase Inhibitor Repotrectinib by Direct Asymmetric Reductive Amination under Batch and Flow

“…To solve the amplification issue, we turned our attention to continuous-flow reactors, which have demonstrated several advantages in hydrogenation reactions. , First, the high surface area-to-volume ratio and efficient mixing increase the reaction efficiency, as reported in previous studies . Additionally, scaling up a batch reaction would greatly increase the amount of hydrogen used, resulting in a significant explosion hazard.…”