Asymmetric Michael Addition of Pyrazolones to β,γ‐Unsaturated α‐Keto Esters Catalyzed by Binaphthyl‐modified Thiourea

An efficient asymmetric synthesis of pyranonaphthoquinones via Michael addition and oxo‐Michael cyclization sequence of 2‐hydroxy‐1,4‐naphthoquinone with (E)‐2‐nitroallylic acetates has been developed. The synthetically useful chiral pyranonaphthoquinone derivatives were obtained in moderate to high yields and high enantioselectivities. This approach offers a facile way to prepare chiral pyranonaphthoquinone derivatives with a wide range of functional group tolerance.

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Enantioselective Organocatalytic Mannich Reaction and Fluorination Sequence of Pyrazolones to Isatin‐derived Ketimines

Jung

Park

Kim

2018

Bulletin Korean Chem Soc

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An efficient asymmetric synthesis of oxindole‐pyrazolone adducts via organocatalytic Mannich reaction of 1‐phenyl‐1H‐pyrazol‐5(4H)‐ones with ketimine derivatives derived from isatins, followed by sequential electrophilic fluorination, has been developed. This approach offers a facile way to prepare chiral 3‐amino‐3‐(4‐fluoropyrazol‐4‐yl)‐substituted oxindole derivatives with a wide range of functional group tolerance.

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Asymmetric Michael Addition of Pyrazolones to β,γ‐Unsaturated α‐Keto Esters Catalyzed by Binaphthyl‐modified Thiourea

Cited by 8 publications

References 42 publications

Synthesis of 2,4‐Diaryl‐4H‐Chromenes via Decarboxylative Alkylation of β‐Keto Acids to ortho‐Quinone Methides as Reactive Intermediates

Synthesis of 2,4‐Diaryl‐4H‐Chromenes via Decarboxylative Alkylation of β‐Keto Acids to ortho‐Quinone Methides as Reactive Intermediates

Highly Diastereo‐ and Enantioselective Organocatalyzed Michael/Oxa‐Michael Sequence: Asymmetric Synthesis of Pyranonaphthoquinone Derivatives

Enantioselective Organocatalytic Mannich Reaction and Fluorination Sequence of Pyrazolones to Isatin‐derived Ketimines

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