Asymmetric Organocatalyzed Cyclization Cascade Reactions of 3,3-Difluoro-2-aryl-3H-indoles and Enamides

Abstract

The direct functionalization of β-C(sp 2 )-H bonds in

Photochemical Synthesis of Chiral Heterocycles via Asymmetric Carbon‐Heteroatom Bond Formation

“…Chiral heterocycles are the most important structural motifs that often exist in various pharmaceuticals, [1] natural products, [2] chiral catalysts or ligands. , [3,4] Due to their significance, tremendous efforts have been devoted to efficiently synthesizing chiral heterocyclic compounds [5][6][7][8][9][10][11][12] In this context, catalytic asymmetric synthesis has been accepted as the most efficient method for accessing enantioenriched compounds in the presence of a chiral environment, which transfers the chirality to the chemical reaction. [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] In particular, catalytic asymmetric reaction via carbon-heteroatom bond formation has attracted great interest in the scientific community for the generation of chiral small molecules in the field of drug discovery and development.…”