Asymmetric oscillations of endoskeletal antibubbles

Kudo, Nobuki; Uzbekov, Rustem; Matsumoto, Ryusaku; Shimizu, Ri-ichiro; Carlson, Craig S.; Anderton, Nicole; Deroubaix, Aurélie; Penny, Clement; Poortinga, Albert T.; Rubin, David M.; Bouakaz, Ayache; Postema, Michiel

doi:10.35848/1347-4065/ab79e7

Cited by 11 publications

(31 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was attributed to nonsymmetric oscillation in the US field, where the antibubble showed larger expansion than contraction because of the incompressible core. Experimental evidence of this effect was acquired with a high‐speed camera for endoskeletal antibubbles 7 . These studies 7,21 suggest that antibubbles have a high potential to improve CE‐US image quality, generating greater higher harmonics, compared to conventional UCAs.…”

Section: Introductionmentioning

confidence: 98%

“… 6 , 21 Encapsulated microbubbles that contain incompressible inclusions and a solid supporting skeleton that suspends the inclusion have been referred to as endoskeletal antibubbles. 7 Figure 1 presents a schematic of an endoskeletal antibubble with a 2% volume inclusion. Theoretical work 21 demonstrated antibubbles to show an increased nonlinear behavior, compared to reference gas bubbles without incompressible cores.…”

Section: Introductionmentioning

confidence: 99%

“…Experimental evidence of this effect was acquired with a high‐speed camera for endoskeletal antibubbles. 7 These studies 7 , 21 suggest that antibubbles have a high potential to improve CE‐US image quality, generating greater higher harmonics, compared to conventional UCAs. Besides this, antibubbles incorporating therapeutic agents in the gas phase can deliver larger doses of therapeutic agents, compared to alternative strategies.…”

Section: Introductionmentioning

confidence: 99%

“…Surrounding the core is the endoskeleton, encapsulated by a silica shell, whose thickness was estimated to be around 1

m, estimated from microscopic images in Ref. 7 . The median reference bubble diameter was estimated to be 6

m. 24 Reference bubbles are filled with air, encapsulated by a silica shell.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Experimental acoustic characterization of an endoskeletal antibubble contrast agent: First results

et al. 2021

Self Cite

View full text Add to dashboard Cite

An antibubble is an encapsulated gas bubble with an incompressible inclusion inside the gas phase. Current-generation ultrasound contrast agents are bubble-based: they contain encapsulated gas bubbles with no inclusions. The objective of this work is to determine the linear and nonlinear responses of an antibubble contrast agent in comparison to two bubble-based ultrasound contrast agents, that is, reference bubbles and SonoVue TM . Methods: Side scatter and attenuation of the three contrast agents were measured, using single-element ultrasound transducers, operating at 1, 2.25, and 3.5 MHz. The scatter measurements were performed at acoustic pressures of 200 and 300 kPa for 1 MHz, 300 kPa, and 450 kPa for 2.25 MHz, and 370 and 560 kPa for 3.5 MHz. Attenuation measurements were conducted at pressures of 13, 55, and 50 kPa for 1, 2.25, and 3.5 MHz, respectively. In addition, a dynamic contrast-enhanced ultrasound measurement was performed, imaging the contrast agent flow through a vascular phantom with a commercial diagnostic linear array probe. Results: Antibubbles generated equivalent or stronger harmonic signal, compared to bubble-based ultrasound contrast agents. The second harmonic sidescatter amplitude of the antibubble agent was up to 3 dB greater than that of reference bubble agent and up to 4 dB greater than that of SonoVue TM at the estimated concentration of 8 × 10 4 bubbles/mL. For ultrasound with a center transmit frequency of 1 MHz, the attenuation coefficient of the antibubble agent was 8.7 dB/cm, whereas the attenuation coefficient of the reference agent was 7.7 and 0.3 dB/cm for SonoVue TM . At 2.25 MHz, the attenuation coefficients were 9.7, 3.0, and 0.6 dB/cm, respectively. For 3.5 MHz, they were 4.4, 1.8, and 1.0 dB/cm, respectively. A dynamic contrast-enhanced ultrasound recording showed the nonlinear signal of the antibubble agent to be 31% greater than for reference bubbles and 23% lower than SonoVue TM at a high concentration of 2 × 10 6 bubbles/mL. Conclusion: Endoskeletal antibubbles generate comparable or greater higher harmonics than reference bubbles and SonoVue TM . As a result, antibubbles with liquid therapeutic agents inside the gas phase have high potential to become a traceable therapeutic agent. K E Y W O R D S harmonic imaging, linear attenuation, nonlinear scattering, pickering-stabilised bubbles, ultrasound contrast agentThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

show abstract

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Surrounding the core is the endoskeleton, encapsulated by a silica shell, whose thickness was estimated to be around 1

m, estimated from microscopic images in Ref. 7 . The median reference bubble diameter was estimated to be 6

m. 24 Reference bubbles are filled with air, encapsulated by a silica shell.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Experimental acoustic characterization of an endoskeletal antibubble contrast agent: First results

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…The resonance frequency of a hydrophobic particle can be estimated from [35], where the optically observed radius of a particle in suspension, which includes the void, is taken for the outer radius, and the dry particle radius is taken for the inner radius. It is noted that the derivation of the oscillating and translating dynamics of a spherically symmetric hydrophobic particle is identical to that of an antibubble [36].…”

Section: Introductionmentioning

confidence: 99%

On the attenuation of ultrasound by pure black tattoo ink

et al. 2021

Self Cite

View full text Add to dashboard Cite

Black tattoo ink comprises hydrophobic carbon black nanoparticles. We hypothesized that black tattoo ink demonstrates transient dynamic activity in an ultrasound field. Brightness-mode sonography was performed on cylindrical receptacles of different bore diameters, filled with black tattoo ink, water, saline, or air, using pulsed ultrasound with center frequencies of 13 MHz and 5 MHz.The scattering from black ink itself lasted less than ten minutes. At 13-MHz sonication, a transient drop in sound speed was observed, as well as a transient lessening of scattering from distal phantom tissue. The linear acoustic attenuation coefficient of pure black ink was measured to be 0.15±0.01 dB cm −1 MHz −1 , equal to whole blood.Low-intensity ultrasonic tattoo removal would be of interest as an alternative to techniques that damage surrounding tissue.

show abstract