“…Most of the excluded studies [11], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63] divided the samples into treated and untreated control groups according to their chronological age and not according to their skeletal age. Seventeen studies [11], [21], [22], [26], [27], [36], [37], [38], [45], [46], [47], [51], [52], [54], [60], [63], [64], [65] had an untreated control group with normal occlusion or with other types of malocclusions other than posterior crossbites. Other reasons for exclusion included, subjecting the control groups to treatment [11], [32], [44], case reports [66], [67], [68], [69], using interventions other than RME [50], [51], [53], [54], [56], [64], [65], [70] or absence of a control group [31], [71], [72].…”