Asymmetric Synthesis of Axially Chiral Compounds

Chiral Phosphoric Acid–Palladium(II) Complex Catalyzed Asymmetric Desymmetrization of Biaryl Compounds by C(sp3)–H Activation

“…Axially chiral biaryl skeletons are important chiral scaffolds present in pharmaceuticals, chiral ligands, and chiral catalysts. Because of their importance, the development of novel methods for the construction of axially chiral compounds has been actively pursued by organic chemists and medicinal chemists . Among the numerous synthetic methods for the construction of chiral biaryl motifs, the desymmetrization of C s -symmetric biaryls is a useful strategy because of the ready availability of the starting material.…”