Asymmetric synthesis of functionalized chiral diphosphines via organopalladium promoted hydrophosphination and diels-alder reactions

Abstract

Scheme 1.1 1.2 Methods for Preparation of Chiral Diphosphines Along with their widespread applications in transition metal catalyzed asymmetric reactions, a number of excellent reports have also documented the synthetic strategies of chiral diphosphines ligands, which can be generally divided into three categories. 1.2.1 Transformation from Chiral Substrates The stereospecific transformations of chiral organic substrates have been shown to provide a straightforward synthetic route to chrial diphosphine ligands, especially those with the chirality located on the side chains (chiral backbone). The most general synthetic approach for their preparation is based on the consecutive nucleophilic substitutions between phosphides and dimesylates, ditosylates or cyclic sulfates of optically active diols. The optically active diols used are usually generated from chiral natural compounds such as optically pure organic acids or derivatives (chiral pool).