Asymmetric Synthesis of Functionalized Nitrophenols via a Copper(II)‐Mediated Bromination/Debromination Aromatization Sequence

Abstract

A stereospecific copper(II)‐mediated bromination/debromination aromatization sequence leading to functionalized nitrophenols from corresponding γ‐nitroketones is described. It provided a simple methodology for the construction of nitrophenols in moderate to good yields and moderate to high enantioselectivities.