Asymmetric Synthesis of Less Accessible α‐Tertiary Amines from Alkynyl Z‐Ketimines

Abstract

Ah ighly stereoselective synthesis of hitherto less accessible chiral a-tertiary amines with multiple structurally similar linear carbon chains was achieved through chiral auxiliary mediated addition of organolithium reagents to the geometrically well-controlled alkynyl Z-ketimines.T his stereoselective nucleophilic addition offers ageneral approach to the asymmetric synthesis of nitrogen-containing chiral materials.Scheme 3. Asymmetric synthesis of previously less accessible a-tertiary amines. D.r.o f25 was determined by 1 H-NMR.