Asymmetric transfer hydrogenation of aromatic ketones catalyzed by the iridium hydride complex under ambient conditions

Asymmetric hydrosilylation, transfer hydrogenation and hydrogenation of ketones catalyzed by iridium complexes

“…in 89% yield after 63 h with a substrate-to-catalyst molar ratio of 10,000:1. In addition, the reaction was neither affected by air nor by the addition of water [56]. This catalytic system is also efficient in the asymmetric transfer hydrogenation of aromatic ketones with HCOONa in water, giving the corresponding optically active alcohols again in high yields and excellent e.e.…”

Ruthenium(III) bis-bidentate Schiff base complexes mediated transfer hydrogenation of imines

“…However, the appropriate choice of metal precursors and the reaction conditions are crucial for catalytic properties. Further, the transition metal catalyzed transfer hydrogenation of ketones and imines using isopropanol as hydrogen source has shown to be an effective method for forming alcohols and amines in organic synthesis [7][8][9][10][11][12]. Though most of the catalysts used for this purpose are mainly based on Rh and Ir systems [10][11][12], ruthenium based catalytic systems are found to be effective in the transfer hydrogenation of ketones [7b-9] and imines [7a,13,14].…”

Enantioselective Synthesis of Alcohols and Amines by Iridium‐Catalyzed Hydrogenation, Transfer Hydrogenation, and Related Processes

“…[140][141][142] For example, with 2 , 1,1-diphenylacetone was reduced in 2-PrOH under base-free conditions with an ee of 99 % using a S/C ratio as high as 10000. [141] The use of a phase-transfer catalyst, or introduction of sodium sulfonate groups in the ligands, enabled the system to operate in H 2 O/2-PrOH mixtures. [143,144] With the diaminoA…”