Asymmetrical distributions of muscarinic receptor binding in the hippocampus of female rats

Wolff, Samuel C.; Hruska, Zuzana; Nguyen, Lieuko; Dohanich, Gary P.

doi:10.1016/j.ejphar.2008.04.002

Cited by 14 publications

(9 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Under urethane anesthesia, theta oscillations are sensitive to atropine, a blocker of muscarinic receptors1516. Interestingly, muscarinic receptors have been reported to mediate gamma oscillations in the hippocampus17 and are more densely distributed in the right hippocampus in rats18. Moreover, rats reared in ENR express higher cortical and hippocampal levels of nerve growth factor transcript, a neurotrophin important for development and maintenance of cholinergic neurons19.…”

Section: Discussionmentioning

confidence: 99%

Experience enhances gamma oscillations and interhemispheric asymmetry in the hippocampus

2013

View full text Add to dashboard Cite

Gamma oscillations are implicated in higher-order brain functions such as cognition and memory, but how an animal’s experience organizes these gamma activities remains elusive. Here we show that the power of hippocampal theta-associated gamma oscillations recorded during urethane anesthesia tends to be greater in rats reared in an enriched environment than those reared in an isolated condition. This experience-dependent gamma enhancement is consistently larger in the right hippocampus across subjects, coinciding with a lateralized increase of synaptic density in the right hippocampus. Moreover, interhemispheric coherence in the enriched environment group is significantly elevated at the gamma frequency. These results suggest that enriched rearing sculpts the functional left–right asymmetry of hippocampal circuits by reorganization of synapses.

show abstract

Section: Discussionmentioning

confidence: 99%

Experience enhances gamma oscillations and interhemispheric asymmetry in the hippocampus

2013

View full text Add to dashboard Cite

show abstract

“…DMv was similar to CA2, and DMd, with its very low GABA A densities, was comparable to CA3. M receptors were more highly expressed in the marmoset and the rodent hippocampus compared with the pigeon HF, but nACh showed higher densities in pigeons compared with rodents (Pauly et al, ; Kraemer et al, ; Topic et al, ; Wolff et al, ; Cremer et al, ). In pigeons, cholinergic binding sites nicely discriminated among the different subdivisions; however, no pattern was observed to indicate any correspondence among mammalian and avian hippocampal substructures based on density variation in cholinergic receptors (Table ).…”

Section: Discussionmentioning

confidence: 99%

“…The conclusion of this summary is illustrated in Figure . (1) Palomero‐Gallagher et al, ; (2) Topic et al, ; (3) Kraemer et al, ; (4) Zilles et al, ; (5) Martens et al, 1998; (6) Cremer et al, ; (7) Cremer et al, ; (8) Wolff et al, ; (9) Zavitsanou et al, 2010; (10) Savosta et al, 1986; (11) Cremer et al, ; (12) Sihver et al, ; (13) our unpublished data.…”

Section: Discussionmentioning

confidence: 99%

Distribution of neurotransmitter receptors and zinc in the pigeon (Columba livia) hippocampal formation: A basis for further comparison with the mammalian hippocampus

Herold¹,

Bingman

Ströckens

et al. 2014

J of Comparative Neurology

116

View full text Add to dashboard Cite

The avian hippocampal formation (HF) and mammalian hippocampus share a similar functional role in spatial cognition, but the underlying neuronal mechanisms allowing the functional similarity are incompletely understood. To understand better the organization of the avian HF and its transmitter receptors, we analyzed binding site densities for glutamatergic AMPA, NMDA, and kainate receptors; GABAA receptors; muscarinic M1 , M2 and nicotinic (nACh) acetylcholine receptors; noradrenergic α1 and α2 receptors; serotonergic 5-HT1A receptors; dopaminergic D1/5 receptors by using quantitative in vitro receptor autoradiography. Additionally, we performed a modified Timm staining procedure to label zinc. The regionally different receptor densities mapped well onto seven HF subdivisions previously described. Several differences in receptor expression highlighted distinct HF subdivisions. Notable examples include 1) high GABAA and α1 receptor expression, which rendered distinctive ventral subdivisions; 2) high α2 receptor expression, which rendered distinctive a dorsomedial subdivision; 3) distinct kainate, α2 , and muscarinic receptor densities that rendered distinctive the two dorsolateral subdivisions; and 4) a dorsomedial region characterized by high kainate receptor density. We further observed similarities in receptor binding densities between subdivisions of the avian and mammalian HF. Despite the similarities, we propose that 300 hundred million years of independent evolution has led to a mosaic of similarities and differences in the organization of the avian HF and mammalian hippocampus and that thinking about the avian HF in terms of the strict organization of the mammalian hippocampus is likely insufficient to understand the HF of birds.

show abstract

“…Before each autoradiographic assay, the sections were allowed to thaw and dry for 20 min at 22°C. The slides were processed as shown in the Table 1, according to the references: 1) (Wolff et al. 2008); 2) (Spurden et al.…”

Section: Methodsmentioning

confidence: 99%

Near‐complete adaptation of the PRiMA knockout to the lack of central acetylcholinesterase

Farár

Mohr

Legrand

et al. 2012

Journal of Neurochemistry

View full text Add to dashboard Cite

Acetylcholinesterase (AChE) rapidly hydrolyzes acetylcholine. At the neuromuscular junction, AChE is mainly anchored in the extracellular matrix by the collagen Q, whereas in the brain, AChE is tethered by the proline-rich membrane anchor (PRiMA).The AChE-deficient mice, in which AChE has been deleted from all tissues, have severe handicaps. Surprisingly, PRiMA KO mice in which AChE is mostly eliminated from the brain show very few deficits. We now report that most of the changes observed in the brain of AChE-deficient mice, and in particular the high levels of ambient extracellular acetylcholine and the massive decrease of muscarinic receptors, are also observed in the brain of PRiMA KO. However, the two groups of mutants differ in their responses to AChE inhibitors. Since PRiMA-KO mice and AChE-deficient mice have similar low AChE concentrations in the brain but differ in the AChE content of the peripheral nervous system, these results suggest that peripheral nervous system AChE is a major target of AChE inhibitors, and that its absence in AChE-deficient mice is the main cause of the slow development and vulnerability of these mice. At the level of the brain, the adaptation to the absence of AChE is nearly complete.

show abstract

Asymmetrical distributions of muscarinic receptor binding in the hippocampus of female rats

Cited by 14 publications

References 38 publications

Experience enhances gamma oscillations and interhemispheric asymmetry in the hippocampus

Experience enhances gamma oscillations and interhemispheric asymmetry in the hippocampus

Distribution of neurotransmitter receptors and zinc in the pigeon (Columba livia) hippocampal formation: A basis for further comparison with the mammalian hippocampus

Near‐complete adaptation of the PRiMA knockout to the lack of central acetylcholinesterase

Contact Info

Product

Resources

About