2022
DOI: 10.3389/fphy.2022.894797
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Asymmetrical Illumination Enables Lipid Droplets Segmentation in Caenorhabditis elegans Using Epi-Illumination Dark Field Microscopy

Abstract: Lipid droplets are the major organelles for fat storage in a cell and analyzing lipid droplets in Caenorhabditis elegans (C. elegans) can shed light on obesity-related diseases in humans. In this work, we propose to use a label free scattering-based method, namely dark field microscopy, to visualize the lipid droplets with high contrast, followed by deep learning to perform automatic segmentation. Our method works through combining epi-illumination dark field microscopy, which provides high spatial resolution,… Show more

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