Asymmetry in CT Scan Measures of Thigh Muscle 2 Months After Hip Fracture: The Baltimore Hip Studies

Miller, Ram R.; Eastlack, Marty; Hicks, Gregory E.; Alley, Dawn E.; Shardell, Michelle; Orwig, Denise; Goodpaster, Bret H.; Chomentowski, Peter J.; Hawkes, William; Hochberg, Marc C.; Ferrucci, Luigi; Magaziner, Jay

doi:10.1093/gerona/glv053

Cited by 9 publications

(10 citation statements)

References 32 publications

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“…A single scanning site was used to obtain echogenicity measures in this work. While the mid-thigh is a body region frequently included in muscle composition research [ 27 , 28 , 54 ], the association between echogenicity and metabolic status may vary with different scanning locations. Importantly, the study participants were ambulatory patients enrolled at an urban U.S. VA medical center and may differ from patients in hospital catchment areas that service rural communities and other geographical locations.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical reference standards for body composition and muscle tissue composition estimates in this study were DXA and CT scanning, respectively [ 5 , 25 , 26 ]. The CT scans, and corresponding ultrasound scans, were taken at the anterior mid-thigh given the previous use of this site to estimate IMAT [ 3 , 27 , 28 , 29 , 30 ]. The physical status of the participants was represented by performance-based assessments.…”

Section: Methodsmentioning

confidence: 99%

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The Comparative Associations of Ultrasound and Computed Tomography Estimates of Muscle Quality with Physical Performance and Metabolic Parameters in Older Men

Harris‐Love

Avila

Adams

et al. 2018

JCM

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Estimates of muscle tissue composition may have greater prognostic value than lean body mass levels regarding health-related outcomes. Ultrasound provides a relatively low cost, safe, and accessible mode of imaging to assess muscle morphology. The purpose of this study was to determine the construct validity of muscle echogenicity as a surrogate measure of muscle quality in a sample of older, predominantly African American (AA) participants. We examined the association of rectus femoris echogenicity with mid-thigh computed tomography (CT) scan estimates of intra- and intermuscular adipose tissue (IMAT), basic metabolic parameters via blood sample analysis, muscle strength, and mobility status. This observational study was conducted at a federal medical center and included 30 community-dwelling men (age, 62.5 ± 9.2; AA, n = 24; Caucasian, n = 6). IMAT estimates were significantly associated with echogenicity (r = 0.73, p < 0.001). Echogenicity and IMAT exhibited similar associations with the two-hour postprandial glucose values and high-density lipoproteins values (p < 0.04), as well as grip and isokinetic (180°/s) knee extension strength adjusted for body size (p < 0.03). The significant relationship between ultrasound and CT muscle composition estimates, and their comparative association with key health-related outcomes, suggests that echogenicity should be further considered as a surrogate measure of muscle quality.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The Comparative Associations of Ultrasound and Computed Tomography Estimates of Muscle Quality with Physical Performance and Metabolic Parameters in Older Men

Harris‐Love

Avila

Adams

et al. 2018

JCM

View full text Add to dashboard Cite

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“…10,11 However, there are a few studies with CT scan imaging that document changes in thigh muscles between the fractured and non-fractured hip. 7 To our knowledge, there have been no reports involving CT scan examination of the gluteus medius muscle in postoperative femoral intertrochanteric fractures. In the current study, the CSA of the gluteus medius muscle was significantly decreased among the middle and distal part, found as continued oval muscular defect, reflecting direct damage during greater trochanteric reaming.…”

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

“…Adipose tissue in and around muscle bundles within each muscle group was distinguished by a bimodal image histogram resulting from the distribution of CT numbers in adipose tissue and muscle. 6 The ATR of the gluteus medius muscle was represented as the ratio of the area of intramuscular adipose tissue (À100 to À50 in Hounsfield Units, HU) against the CSA (0-100 HU) 7,8 ( Figure 3). …”

Section: Ct Measurementsmentioning

confidence: 99%

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Decreased postoperative gluteus medius muscle cross-sectional area measured by computed tomography scan in patients with intertrochanteric fractures nailing

Noda

Saegusa

Takahashi

et al. 2017

J Orthop Surg (Hong Kong)

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Background: In patients with femoral intertrochanteric fractures treated by cephalomedullary (CM) nailing, abduction force reportedly decreased by 25-30% during the postoperative follow-up period. The purpose of the current study is to evaluate the cross-sectional area (CSA) and adipose tissue ratio (ATR) of the gluteus medius muscle on the postoperative computed tomography (CT) view, expecting this graphic study will support clinical results. Materials and methods: A total of 27 patients with femoral intertrochanteric fractures treated by CM femoral nail implants completed the study. The mean age at osteosynthesis was 83 years (range: 72-94 years). The mean postoperative follow-up period was 23 months. The three CT axial slice views were defined as slices A, B, and C corresponding to proximal, midway, and distal part of gluteus medius, respectively. The CSA and ATR were assessed bilaterally. Results: The mean and standard deviation of CSA values (mm 2 ) between the nonoperated/ operated side were as follows: slice A: 2225.8 + 621.2/1984.5 + 425.8; slice B: 2145.1 + 538.3/1854.9 + 383.9; and slice C: 1711.0 + 459.0/1434.5 + 396.9 (p < 0.01 in slices A, B, and C). The mean and standard deviation of ATR values (%) from the nonoperative/ operative side were as follows: slice A: 2.8 + 1.7/ 5.2 + 3.5; slice B: 2.7 + 1.9/4.6 + 3.2; and slice C: 3.6 + 3.0/4.8 + 3.2 (p < 0.01 in slices A and B and p < 0.05 in slice C). Conclusion: Our image findings documented that gluteus medius is significantly changed in CSA and ATR. The damage possibly triggers decrease in muscular strength of hip abduction in the postoperative follow-up period. This measurement is objective, and needed no patient's endurance and cooperation.

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Trunk Muscle Composition 2 Months After Hip Fracture: Findings From the Baltimore Hip Studies

Hicks

Shardell

Miller

et al. 2019

Archives of Physical Medicine and Rehabilitation

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Asymmetry in CT Scan Measures of Thigh Muscle 2 Months After Hip Fracture: The Baltimore Hip Studies

Abstract: The observed asymmetry is consistent with the effect of disuse and inflammation in the affected limb along with training effects in the unaffected limb due to the favoring of this leg with ambulation during the postfracture period.

Cited by 9 publications

References 32 publications

The Comparative Associations of Ultrasound and Computed Tomography Estimates of Muscle Quality with Physical Performance and Metabolic Parameters in Older Men

The Comparative Associations of Ultrasound and Computed Tomography Estimates of Muscle Quality with Physical Performance and Metabolic Parameters in Older Men

Decreased postoperative gluteus medius muscle cross-sectional area measured by computed tomography scan in patients with intertrochanteric fractures nailing

Trunk Muscle Composition 2 Months After Hip Fracture: Findings From the Baltimore Hip Studies

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