Asymmetry of the hexose transfer system in human erythrocytes. Experiments with non‐transportable inhibitors.

Baker, G F; Basketter, David A.; Widdas, W. F.

doi:10.1113/jphysiol.1978.sp012310

Cited by 45 publications

(42 citation statements)

References 9 publications

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“…The effect of 200 mM-ethylidene glucose inside the cells was less than that of 50 mm outside. Although marked, this asymmetry was less than that obtained by Baker et al (1978) 20 mm the saturation fraction of 3-0-methyl glucose for human cells is greater than for new-born guinea-pig cells and this partly compensates for the lower VEX in human cells.…”

Section: -0-methyl Glucose Exchangementioning

confidence: 60%

“…When inhibitors of hexose exchange are present, a relatively simple treatment (Baker et al 1978) predicts that the reciprocal of the exchange flux should be a linear function of the inhibitor concentration and that such a line should intercept a line through 1/VEX parallel to the abscissa at a point corresponding to the half-saturation concentration for the inhibitor.…”

Section: -0-methyl Glucose Exchangementioning

confidence: 99%

“…10 mi for inhibition outside. The corresponding values for human red cells (Baker et al 1978) to make exchange measurements. The results are shown in Fig.…”

Section: -0-methyl Glucose Exchangementioning

confidence: 99%

“…

(Baker, Basketter & Widdas, 1978).3. Methyl-2,3-di-O-methyl-a-D-glucopyranoside (trimethyl glucoside) had K1 values of ca.

…”

mentioning

confidence: 99%

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Asymmetry of hexose transfer system in erythrocytes of fetal and new‐born guinea‐pigs.

Aubby¹,

Widdas²

1980

The Journal of Physiology

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(Baker, Basketter & Widdas, 1978).3. Methyl-2,3-di-O-methyl-a-D-glucopyranoside (trimethyl glucoside) had K1 values of ca. 120 mm and ca. 160 mm for inside and outside inhibition respectively. This is also qualitatively similar to the inhibition in human erythrocytes.4. The inhibition produced by phlorizin, phloretin and Cytochalasin B was also studied in the erythrocytes of new-born guinea-pigs. The results were qualitatively similar to those for human erythrocytes but the inhibitory affinities were different. Thus while phlorizin and phloretin had higher affinities for the inhibition of exchange in new-born guinea-pig cells than human cells, the affinity of Cytochalasin B was less for new-born guinea-pig cells than for human cells.5. It is concluded that the hexose transfer system in fetal and new-born guineapig red cells has asymmetric affinities similar to the system in human red cells but with different values ofthe inhibitory constants. The differences may represent species variations in a structural protein serving identical functions in the two species.6. The possibility that fetal red cells with their facilitated transfer system play a role in sugar transport is discussed.

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Section: -0-methyl Glucose Exchangementioning

confidence: 60%

Section: -0-methyl Glucose Exchangementioning

confidence: 99%

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Asymmetry of hexose transfer system in erythrocytes of fetal and new‐born guinea‐pigs.

Aubby¹,

Widdas²

1980

The Journal of Physiology

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“…Examination of these results and others already published (Baker, Basketter & Widdas, 1978) has shown that they are difficult to interpret by simple carrier kinetics (Widdas, 1985). The collection of data from earlier experiments and the filling in with Sen-Widdas experiments at 16-17°C for 3-0-methyl glucose exits, not previously available, has provided data which could be used in a fuller appraisal of the results in terms of the asymmetric carrier equations of Regen & Tarpley (1974) which were shown by Widdas (1980) to be applicable to experiments with non-transportable inhibitors.…”

Section: G F Baker And-w F Widdasmentioning

confidence: 99%

Parameters for 3‐O‐methyl glucose transport in human erythrocytes and fit of asymmetric carrier kinetics.

Baker

Widdas

1988

The Journal of Physiology

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SUMMARY1. Equilibrium exchanges in the range of 2-40 mM-3-O-methyl glucose at 16°C suggested that the half-saturation concentration for exchange was 22 mm and that the maximum velocity (Vmax) was ca. 149 mmol 1-1 min-'.2. Initial rates of exchange influx from 1, 2, 4 and 8 mm into 76 mm solution gave a half-saturation value of 3-6 mm and a Vmax of 122 mmol-V min-'.3. The non-transportable inhibitor 4,6-O-ethylidene-a-D-glucopyranose (ethylidene glucose) acting on the outside of the cells inhibited 3-0-methyl glucose exchanges at 16°C with an inhibition constant (KI) of ca. II mm.4. Sen-Widdas exit experiments gave the half-saturation for 3-0-methyl glucose at 16°C as only ca. 2 mm and the KI for ethylidene glucose as ca. 4 mM.5. Efflux inhibitions by ethylidene glucose are satisfactorily predicted by the asymmetric carrier kinetics of Regen & Tarpley (1974) when using the parameters derived from the exchange experiments but not with parameters from Sen-Widdas exits.

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K 3 Projective Models in Scrolls

Johnsen¹,

Knutsen²

2004

Lecture Notes in Mathematics

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The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specif ic statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.Typesetting: Camera-ready T E X output by the author SPIN: 10999523 41/3142/ du -543210 -Printed on acid-free paper PrefaceThe cover picture shows a smooth quartic surface in space, the simplest example of a projective model of a K3 surface. In the following pages we will encounter many more examples of models of such surfaces. The purpose of this volume is to study and classify projective models of complex K3 surfaces polarized by a line bundle L such that all smooth curves in |L| have non-general Clifford index. Such models are in a natural way contained in rational normal scrolls.These models are special in moduli in the sense that they do not represent the general member in the countable union of 19-dimensional families of polarized K3 surfaces. However, they are of interest because they fill up the set of models in P g for g ≤ 10 not described as complete intersections in projective space or in a homogeneous space as described by Mukai, with a few classificable exceptions.Thus our study enables us to classify and describe all projective models of K3 surfaces of genus g ≤ 10, which is the main aim of the volume.Acknowledgements. We thank Kristian Ranestad, who suggested to study certain projective models of K3 surfaces in scrolls that had shown up in connection with his work on varieties of sums of powers (see [I-R1], [I-R2] and [R-S]). This idea was the starting point of our work.We are also grateful to M. Coppens, G. Fløystad, S. Ishii, S. Lekaus, R. Piene, J. Stevens, S. A. Strømme, B. Toen and J. E. Vatne for useful conversations, and to G. M. Hana for pointing out several mistakes in an earlier version of the manuscript.We also thank Alessandra Sarti who made us the nice picture we have used on the cover.

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Asymmetry of the hexose transfer system in human erythrocytes. Experiments with non‐transportable inhibitors.

Cited by 45 publications

References 9 publications

Asymmetry of hexose transfer system in erythrocytes of fetal and new‐born guinea‐pigs.

Asymmetry of hexose transfer system in erythrocytes of fetal and new‐born guinea‐pigs.

Parameters for 3‐O‐methyl glucose transport in human erythrocytes and fit of asymmetric carrier kinetics.

K 3 Projective Models in Scrolls

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