Asymptomatic Bacteriuria among Pregnant Women at University Hospital in Uyo, Nigeria: Prevalence, Risk Factors and Characteristics

Akpan, Nseobong Godwin; Onwuezobe, Ifeanyi A; Antia, Ukponobong E.

doi:10.9734/ajmah/2017/31408

Cited by 11 publications

(19 citation statements)

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“…Urinary tract infection is a severe threat in our locality, especially to pregnant women living in both urban and rural areas. 10,[25][26] Asymptomatic bacteriuria is a frequently occurring bacterial infection of the urinary tract that requires medical treatment even during pregnancy. Therefore, there is need to constantly monitor the prevalence of uropathogens causing infection in pregnant women in order to prevent complications associated with its occurrence through prompt medical treatment.…”

Section: Microorganisms (N) Discussionmentioning

confidence: 99%

“…These abnormal conditions were also reported in previous documented studies in Nigeria agreeing to the result of this study. 10,[25][26] Pyuria were detected in these women because they may have had coinfection with Chlamydia, urogenital tuberculosis and renal myco-bacterial infections. Bacteriuria may be present without pyuria due to contamination or inappropriate collection of the sample, production of leucocyte destroying enzyme by bacteria (leukocidin by Staphylococcus aureus), neutropaenia (people with poor cell-mediated immune response) while gestational proteinuria and glycosuria may be due to physiological challenges of pregnancy not related to the presence of bacterial infections.…”

Section: Microorganisms (N) Discussionmentioning

confidence: 99%

“…5,6 Researches have shown that the incidence of asymptomatic bacteriuria (ASB) in pregnant women ranges from 3.5% to 55%; where higher incidence occurred in developing countries. [7][8][9][10] The development of resistance to previously effective antibiotics by common uropathogens has been reported globally in the past few years. [7][8] Traditional birth attendants (TBAs) are individuals; either skills or unskilled who assist women in childbirth and also provide care during pregnancy, labour, postnatal period and give advice about childcare.…”

mentioning

confidence: 99%

“…21,22 Poverty and low educational status have associated with patronage and delivery of pregnant women by traditional birth attendants. 7,[10][11][12][13]23 These factors have also been shown to be associated with ASB infection in pregnant women. 9,13 Numerous research on prevalence of asymptomatic urinary tract infection among pregnant women in Akwa Ibom, Nigeria are availablebut to the best of our knowledge, none have focused on pregnant women receiving ante-natal care in traditional birth attendant homes.…”

mentioning

confidence: 99%

“…9,13 Numerous research on prevalence of asymptomatic urinary tract infection among pregnant women in Akwa Ibom, Nigeria are availablebut to the best of our knowledge, none have focused on pregnant women receiving ante-natal care in traditional birth attendant homes. 10,25,26 Additionally, the health status of pregnant woman attending unorthodox birth centers (traditional and religious birth attendant homes) in villages within Akwa Ibom state has been neglected and researches have shown that reasonable number of pregnant women in the country deliver their babies outside modern health facilities. 9,14,16,17,24 There is paucity of documented research on the prevalence of uropathogens and antimicrobial susceptibility profiles of ASB among pregnant women receiving antenatal care in traditional birth attendant homes in Ikono, Akwa Ibom State, Nigeria.…”

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confidence: 99%

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Uropathogens and antimicrobial susceptibility profiles of asymptomatic bacteriuria among pregnant women receiving antenatal care in traditional birth attendants homes in Ikono, Akwa- Ibom State, Nigeria

Umoyen

Akpan

Sunday

et al. 2021

Int J Reprod Contracept Obstet Gynecol

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Background: Asymptomatic bacteriuria (ASB) in pregnancy is associated with adverse maternal and obstetric outcomes if untreated. The aim of this study was to determine the prevalence and susceptibility profile of ASB among pregnant women attending antenatal clinics in traditional birth attendant homes in Ikono, Akwa-Ibom State.Methods: The study was a cross sectional survey using 350 pregnant women with ASB. Mid-stream clean catch urine samples were collected from the women using sterile containers. The urine samples were cultured, bacterial colonies were identified and antibiotic sensitivity was done. Data was analyzed using SPSS version 20.0 and significant was set at ≤0.05.Results: The overall prevalence was 33.4% using 350 asymptomatic pregnant women. The mean age was 26.21±3.6 years and aged 27-32 have the highest prevalence (13.4) of ASB. 55.1% attained primary school, while 33.4% had informal education, monoparous (54%), 3rd trimester was 44.6% with 15.8% positive cases. Multigravidae was 71.1% with 19.4% positive cases. There was significant association of age, education, parity, occupation, monthly income, etc with ASB. The most common isolates were Escherichia coli (29.9%), then Klebsiella pneumonia (19.7%). Pseudomonas aeruginosa was susceptible to gentamicin (92%), Ciprofloxacin (83%) imipenam (83%) and azetronam (75%), while Staphylococcus saprophyticus was susceptible to imipenam (90%), then gentamicin at 80%. Multi-drug resistant were widespread in most of the isolates.Conclusions: Multi-drug resistant were observed in most of the isolates. Continuous and collaborative surveillance of ASB and antimicrobial resistance pattern are essential to reduce the consequence of asymptomatic bacteriuria in pregnant women.

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Section: Microorganisms (N) Discussionmentioning

confidence: 99%

Section: Microorganisms (N) Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Uropathogens and antimicrobial susceptibility profiles of asymptomatic bacteriuria among pregnant women receiving antenatal care in traditional birth attendants homes in Ikono, Akwa- Ibom State, Nigeria

Umoyen

Akpan

Sunday

et al. 2021

Int J Reprod Contracept Obstet Gynecol

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Urinary Tract Infection and Associated Factors among Pregnant Women Receiving Antenatal Care at a Primary Health Care Facility in the Northern Region of Ghana

Vicar,

Acquah,

Wallana

et al. 2023

International Journal of Microbiology

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Urinary tract infection (UTI) is frequently encountered during pregnancy and is associated with adverse maternal, fetal, and neonatal effects. However, very little information is available on the prevalence of UTI among pregnant women in the northern part of Ghana, a region with a high birth rate. This study employed a cross-sectional analysis of the prevalence, antimicrobial profile, and risk factors associated with UTI in 560 pregnant women attending primary care for antenatal check-ups. Sociodemographic obstetrical history and personal hygiene information were obtained using a well-structured questionnaire. Afterward, clean catch mid-stream urine samples were collected from all participants and subjected to routine microscopy examination and culture. Of 560 pregnant women, 223 cases (39.8%) were positive for UTI. There was a statistically significant association between sociodemographic, obstetric, and personal hygiene variables and UTI ( p < 0.0001 ). Escherichia coli (27.8%) was the commonest bacterial isolate followed by CoNS (13.5%) and Proteus species (12.6%). These isolates exhibited greater resistance to ampicillin (70.1–97.3%) and cotrimoxazole (48.1–89.7%) but were fairly susceptible to gentamycin and ciprofloxacin. Gram-negative resistance to meropenem was up to 25.0%, and Gram positives resistance to cefoxitin and vancomycin was up to 33.3% and 71.4% respectively. The current findings extend our knowledge of the high frequency of UTIs and associated risk factors in pregnant women with E. Coli being the predominant and usual isolate. Variation existed in the resistance pattern of isolates to various drugs, underscoring the need to perform urine culture and susceptibility before treatment.

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Genotypic Detection of the Virulence Factors of Uropathogenic Escherichia Coli (Upec) Strains Isolated From Pregnant Females and Their Correlation With Antibiotic Resistance Pattern

Ahmed

2021

Al-Azhar Journal of Pharmaceutical Sciences

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Urinary Tract Infections (UTIs) during pregnancy are among the most common infections worldwide and can lead to poor perinatal and maternal outcomes, especially in developing countries and requires medical treatment as soon as it is detected. Virulent and resistant strains of Escherichia coli are the most important causative agents for UTIs. The present investigation aimed to detect virulence factors of Uropathogenic Escherichia coli (UPEC), including pap, fim, sfa, aer and hly genes in isolates collected from symptomatic and asymptomatic pregnant females by multiplex polymerase chain reaction (PCR) assay and determine their correlation with antibiotic resistance patterns. Two hundred urine samples collected from pregnant females with or without symptoms of UTI were admitted to antenatal clinic at Obstetrics and Gynecology Department of Al-Zahraa University Hospital in Cairo. Out of 200 cultured urine samples, the cultures that showed ≥ 10 5 CFU/ml were identified to have significant growth. Found significant bacteriuria was detected in 61 samples and these samples selected for further analysis in this study, the overall prevalence of UTI among pregnant females was (30.5%). Symptomatic pregnant females with UTI were (48.5%) more than asymptomatic (11.3%). The most frequently isolated species was S. saprophyticus (35.0%), followed by E. coli (26.2%), S .aureus (19.4%), C .albicans (5.8%), S. epidermidis (2.9%) and each of K. pneumonia, K .oxytoca, P .vulgaris, E.fecalis, Bacillus spp were (1.9%), while P. auroginosa had the least percentage of isolation (1.0%). Antimicrobial susceptibility pattern was done for 27 UPEC isolates showed the highest level of resistance (100%) against β-lactams as (Ampicillin, Penicillin and Ceftriaxone), nitrofurantoin, and ampicillin/sulbactam, while the lowest level of resistance (66.7%) against Cotrimoxazole. Multiple drug resistance (resistance to two or more drugs) was observed in (100%) of the UPEC isolates. The higher level of resistance to antibiotics was observed in symptomatic bacteriuria more than asymptomatic. Among two predominant uropathogens, E. coli showed complete resistance up to 5 different antibiotics of total 11 antibiotics (45.5%) while S. saprophyticus showed complete resistance (18.2%), so E. coli showed higher virulence and resistance than S. saprophyticus to cause UTI, so subjected to Multiplex PCR to detect its virulence factors, which included pap, fim, sfa, aer and hly genes The adhesive fimH gene was the most frequent in UPEC isolates (92.6%). These virulence genes detected from total UPEC isolates of symptomatic cases were higher than asymptomatic. On the other hand, UPEC strains carrying the virulence genes were more resistant to the antibiotics used, so these observations confirm the important role of virulence genes of UPEC in in existence of symptoms of UTI and the drug resistance.

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Asymptomatic Bacteriuria among Pregnant Women at University Hospital in Uyo, Nigeria: Prevalence, Risk Factors and Characteristics

Cited by 11 publications

References 0 publications

Uropathogens and antimicrobial susceptibility profiles of asymptomatic bacteriuria among pregnant women receiving antenatal care in traditional birth attendants homes in Ikono, Akwa- Ibom State, Nigeria

Uropathogens and antimicrobial susceptibility profiles of asymptomatic bacteriuria among pregnant women receiving antenatal care in traditional birth attendants homes in Ikono, Akwa- Ibom State, Nigeria

Urinary Tract Infection and Associated Factors among Pregnant Women Receiving Antenatal Care at a Primary Health Care Facility in the Northern Region of Ghana

Genotypic Detection of the Virulence Factors of Uropathogenic Escherichia Coli (Upec) Strains Isolated From Pregnant Females and Their Correlation With Antibiotic Resistance Pattern

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