Asymptomatic bilateral pulmonary embolism in Churg–Strauss syndrome: Figure 1.

Maria, André Soares; Guilpain, Philippe; Forestier, Alexandra; Delhom, E.; Schiffman, Alisa B.; Rivière, Sophie; Kien, A. Khau Van; Leray‐Moragues, Hélène; Serre, Isabelle; Vincent, Thomas N.; Jf, Eliaou; Quellec, A. Le

doi:10.1183/09059180.00007911

Cited by 1 publication

(1 citation statement)

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“…Pulmonic venous thrombosis has been reported with a prevalence of 8.1% ( 240 ) that could present at first diagnosis or remission ( 241 ). It presents in ANCA negative patients ( 242 ). The pathophysiological mechanisms remain unclear and speculative ( 243 ), but it seems to be related to the prothrombotic properties of the eosinophil granule proteins, such as the cationic proteins that can bind the Hageman Factor (XII) and activate the intrinsic pathway of coagulation and interfere with the anticoagulant activity of endogenous heparan sulfate ( in vitro ) ( 244 ), along with the potential role of other eosinophil products such as the hypothiocyanous acid by the induction of tissue factor activity ( 245 ).…”

Section: Cmr Techniquementioning

confidence: 99%

Cardiac Magnetic Resonance in Rheumatology to Detect Cardiac Involvement Since Early and Pre-clinical Stages of the Autoimmune Diseases: A Narrative Review

Sierra-Galan

Bhatia

Alberto-Delgado

et al. 2022

Front. Cardiovasc. Med.

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Autoimmune diseases (ADs) encompass multisystem disorders, and cardiovascular involvement is a well-known feature of autoimmune and inflammatory rheumatic conditions. Unfortunately, subclinical and early cardiovascular involvement remains clinically silent and often undetected, despite its well-documented impact on patient management and prognostication with an even more significant effect on severe and future MACE events as the disease progresses. Cardiac magnetic resonance imaging (MRI), today, commands a unique position of supremacy versus its competition in cardiac assessment and is the gold standard for the non-invasive evaluation of cardiac function, structure, morphology, tissue characterization, and flow with the capability of evaluating biventricular function; myocardium for edema, ischemia, fibrosis, infarction; valves for thickening, large masses; pericardial inflammation, pericardial effusions, and tamponade; cardiac cavities for thrombosis; conduction related abnormalities and features of microvascular and large vessel involvement. As precise and early detection of cardiovascular involvement plays a critical role in improving the outcome of rheumatic and autoimmune conditions, our review aims to highlight the evolving role of CMR in systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), rheumatoid arthritis (RA), systemic sclerosis (SSc), limited sclerosis (LSc), adult-onset Still's disease (AOSD), polymyositis (PM), dermatomyositis (DM), eosinophilic granulomatosis with polyangiitis (EGPA) (formerly Churg-Strauss syndrome), and DRESS syndrome (DS). It draws attention to the need for concerted, systematic global interdisciplinary research to improve future outcomes in autoimmune-related rheumatic conditions with multiorgan, multisystem, and cardiovascular involvement.

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