Asymptomatic colonic metastases from primary squamous cell carcinoma of the lung with a positive fecal occult blood test

Abstract

We describe a 74-year-old man with a colonic metastatic squamous cell carcinoma (SCC) from the lung. His chest X-ray revealed an abnormal shadow in the right upper lobe. Computed tomography (CT) of the chest demonstrated a large lung tumor in the right upper lobe obstructing the right upper bronchus. Bronchoscopy revealed an easy-bleeding tumor in the right upper bronchus that was diagnosed as poorly differentiated squamous cell lung carcinoma. He underwent colonoscopy because he had a positive fecal occult blood test. Colonoscopy revealed a large protruding lesion with central ulceration in the descending colon. Histological examination of the biopsy specimen obtained from the colonic lesion revealed SCC. The lesion was diagnosed as metastatic colonic SCC. He had no abdominal symptoms. He underwent chemotherapy with an infusion of cisplatin 130 mg i.v. day 1, and docetaxel hydrate 100 mg i.v. day 1, repeated every 4 wk, followed by 4 courses of chemotherapy. The primary lesion shrank by less than 10% and was judged to be "Partial Response" (PR) after 3 courses of treatment. The patient still lived 23 wk after the diagnosis of metastatic colonic SCC. Colonic metastasis of primary SCC of the lung is rare.

Analysis of gastrointestinal metastasis of primary lung cancer: Clinical characteristics and prognosis

“…Although certain clinical studies and autopsy series (14)(15)(16) have shown adenocarcinoma to be prominent, as observed in the present study, other clinical studies (3,4) have demonstrated that squamous cell carcinoma, large cell carcinoma and pleomorphic carcinoma are more frequent (5,(17)(18)(19)(20)(21). Therefore, the histological type predominantly associated with gastrointestinal metastasis remains unclear.…”

“…To the best of our knowledge, only a few studies of long-term survival in cases of large bowel metastasis of lung cancer have been published (17,31). In the current study, we hypothesize that the long-term survival in 1 case was due to the presence of solitary metastasis with resectable lesions.…”

Metastatic squamous cell carcinoma to the colon arising from a mature cystic ovarian teratoma

“…Metastatic SCC to the colon has been described in the literature but, typically, these tumors originate from a pulmonary tumor. 4,5 Although metastasis to the rectum from ovarian squamous cell carcinoma has been described, 6,7 to our knowledge, this is the first case of recurrent SCC to the colon arising from the malignant degeneration of a mature cystic teratoma.…”

Metastatic Colon Cancer from Asymptomatic Gastric Stump Cancer: Report of a Rare Case

“…Most CRCs are in the form of adenocarcinomas arising from the colonic mucosa; however, metastatic malignancy in color as a colon is extremely rare. A review of the literature disclosed that only a few cases have reported the occurrence of this rare condition from renal cell carcinoma, bronchogenic cancer [2], and breast cancer [3]. Secondary colonic neogrowth originating from asymptomatic gastric stump is extremely rare.…”