Asymptomatic Cytomegalovirus Viremia Is Associated With Increasd Risk of Pneumocystis and Fungal Infections

Cytomegalovirus infection and graft rejection as risk factors for pneumocystis pneumonia in solid organ transplant recipients: A systematic review and meta‐analysis

“…This association was demonstrated in most studies included in this meta-anal ysis 2,14,19,20,23,26,27. Allograft rejection has been shown to increase the risk of PJP.…”

“…2,[13][14][15]17,19,20,[22][23][24][25][26][27] Table 2 2,[13][14][15]17,19,20,[22][23][24][25][26][27] Table 2 …”

“…Thirteen studies reported the frequencies of cytomegalovirus (CMV) infection in SOT patients with and without PJP. 2,[13][14][15]17,19,20,[22][23][24][25][26][27] Table 2 demonstrates the study populations and the frequency of CMV infection in cases and controls in detail. The association between CMV infection and post-transplant PJP was statistically significant in 6 studies.…”

“…The association between CMV infection and post-transplant PJP was statistically significant in 6 studies. 2,14,19,20,23,26…”

“…Large number of variables have been introduced as potential risk factors for post-transplant PJP. 2,[12][13][14][18][19][20][21][22] Of particular interest, cytomegalovirus infection 2,[13][14][15]17,19,20,[22][23][24][25][26][27] and allograft rejection 2,[13][14][15]17,19,20,[22][23][24][25][26][27] have been frequently shown to increase the likelihood of PJP. However, individual studies demonstrated dissimilar effects and different magnitude of the effect sizes.…”