Asymptomatic gallstones in patients with sickle cell disease: to wait or to operate?

El-Menoufy, Mohamed A.M; El-Barbary, Hany M; Raslan, Salah

doi:10.4103/ejh.ejh_34_18

Cited by 4 publications

(3 citation statements)

References 1 publication

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“…Furthermore, the role of prophylactic cholecystectomy in asymptomatic SCD patients has been highly debated with some literature predicting higher costs and increased mortality, while some literature recommends that almost no asymptomatic patients undergo cholecystectomy due to high risk of complication in SCD patients 19 , 20 . However, in our case prophylactic cholecystectomy could possibly have averted the morbidity.…”

Section: Discussionmentioning

confidence: 99%

Recurrent acute pancreatitis in an adult female with sickle cell disease: A case report

Sharma

Khadka

Sharma

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction and Importance: Although risk factors such as cholelithiasis and vaso-occlusive crises exist in sickle cell disease, acute pancreatitis and its recurrence are considered rare complications manifesting as acute abdomen. Case Presentation: A 33-year-old female with sickle cell disease and established cholelithiasis presented to the center with acute abdomen. After examination, investigation, and contrast enhanced computed tomography, acute pancreatitis was diagnosed. Conservative management was done and cholecystectomy was planned but delayed due to low hemoglobin. In the interval she presented again with similar features and diagnosed with of recurrence. After conservative management and after optimization of patient’s hemodynamic status, laparoscopic cholecystectomy was finally performed. Postoperative period and follow-up visit after 2 months were uneventful. Clinical Discussion: As the features of pancreatitis and vaso-occlusive crisis are similar, the former should be considered as a differential diagnosis of acute abdomen in sickle cell patients. Laparoscopic cholecystectomy is the treatment of choice for symptomatic cholelithiasis in these patients. However, some issues related to management such as preoperative transfusion and prophylactic cholecystectomy are still debated. This uncertainty caused delay in surgery which may have contributed to the recurrence of pancreatitis in our patient. As the risk of recurrence is possible after the first attack, standard guidelines are required for the definite management of the cause. Conclusion: This case report adds to the limited literature on recurrent acute pancreatitis in sickle cell patients and points out the need for studies on developing management guidelines in such patients and need for prophylactic treatment.

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Section: Discussionmentioning

confidence: 99%

Recurrent acute pancreatitis in an adult female with sickle cell disease: A case report

Sharma

Khadka

Sharma

et al. 2023

Annals of Medicine &Amp; Surgery

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“…Upon admission, adequate oxygenation was provided to correct hypoxia along with IV hydration. A straightforward packed red blood cell transfusion (SBCT) was used to increase Hb levels to 10g/dl, along with the administration of hydroxyurea to increase fetal Hb and decrease sickling and anticoagulation therapy to prevent blood clots [ 4 ]. Additionally, folic acid and calcium supplements were given.…”

Section: Case Presentationmentioning

confidence: 99%

“…It is estimated to be around 4% in India compared to 10% in the West [ 3 ]. Gallstones can develop in SCD patients at different ages: 15% before the age of 10, 22% between the ages of 10 and 14, 36% between the ages of 15 and 18, and 70% by the time the patient is over 30 [ 4 ]. Pigment gallstones are more common in people with sickle cell anemia (SCA) and thalassemia.…”

Section: Introductionmentioning

confidence: 99%

Sickle Cell Disease (SCD) Leading to Pulmonary Arterial Hypertension (PAH) and Cholelithiasis (CL)

Chacko¹,

Jadhav²,

Ghewade³

et al. 2023

Cureus

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Sickle cell disease (SCD) consists of a variety of hereditary hemoglobinopathies linked to alterations in the beta component of the hemoglobin (Hb) molecule. Acute SCD manifestations include stroke, acute chest syndrome (ACS), and pain, whereas chronic manifestations include avascular necrosis, chronic renal disease, and gallstones. This case report describes a rare instance of SCD-related pulmonary arterial hypertension (PAH) and cholelithiasis (CL). Following investigations, such as high-resolution CT scan thorax, chest X-ray, two-dimensional echocardiography, and ultrasonography of the abdomen and pelvis, PAH and CL were confirmed. The medical intervention mainly involved oxygenation, IV fluids, IV antibiotics, simple packed red blood cell transfusion (SBCT), folic acid, calcium supplementation, hydroxyurea, chest physiotherapy, and respiratory muscle strengthening exercises. The surgical intervention for CL was planned. Hence, the learning point from this case is that early multidisciplinary approach should be taken in order to control the progression of SCD.

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Outcomes after Cholecystectomy in Patients with Sickle Cell Disease: Does Acuity of Presentation Play a Role?

Ramdath

Zeineddin

Nizam

et al. 2020

Journal of the American College of Surgeons

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Asymptomatic gallstones in patients with sickle cell disease: to wait or to operate?

Cited by 4 publications

References 1 publication

Recurrent acute pancreatitis in an adult female with sickle cell disease: A case report

Recurrent acute pancreatitis in an adult female with sickle cell disease: A case report

Sickle Cell Disease (SCD) Leading to Pulmonary Arterial Hypertension (PAH) and Cholelithiasis (CL)

Outcomes after Cholecystectomy in Patients with Sickle Cell Disease: Does Acuity of Presentation Play a Role?

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