Asymptomatic oral human papillomavirus (HPV) infection in women with a histopathologic diagnosis of genital HPV

Peixoto, Andrea P.; Campos, Gúbio Soares; Queiroz, Leila Brito; Sardi, Sílvia Inês

doi:10.2334/josnusd.53.451

Cited by 19 publications

(19 citation statements)

References 34 publications

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“…Previous investigations have identified factors and behavioral habits that might facilitate viral infections by interfering with the integrity of the oral mucosa or the homeostatic balance in the oral cavity [5,12,20,23,24]. In the present study, however, demographic variables and behavioral habits were not associated with HPV infection.…”

Section: Discussioncontrasting

confidence: 74%

Oral and cervical HPV infection in HIV‐positive and HIV‐negative women attending a sexual health clinic in São Paulo, Brazil

Lima

Braz‐Silva

Pereira

et al. 2014

Intl J Gynecology & Obste

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Section: Discussioncontrasting

confidence: 74%

Oral and cervical HPV infection in HIV‐positive and HIV‐negative women attending a sexual health clinic in São Paulo, Brazil

Lima

Braz‐Silva

Pereira

et al. 2014

Intl J Gynecology & Obste

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“…Although studies have reported multiple symptoms of hospitalized patients with 2019-nCoV infection 3,20 , some cases at home might be asymptomatic. It is worth noting that, a previous study showed that 99% of the patients had no clinical manifestation of oral human papillomavirus (HPV), but HPV DNA was detected in 81% of oral mucosa samples, and anti-HPV IgA was detected in the saliva of 44% of the patients 21 . Likewise, although 2019-ncov infection hardly presented oral symptoms, the ACE2 expression in the oral cavity indicated that the oral infection route of 2019-nCoV cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

et al. 2020

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It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection. To investigate the potential route of 2019-nCov infection on the mucosa of oral cavity, bulk RNA-seq profiles from two public databases including The Cancer Genome Atlas (TCGA) and Functional Annotation of The Mammalian Genome Cap Analysis of Gene Expression (FANTOM5 CAGE) dataset were collected. RNA-seq profiling data of 13 organ types with para-carcinoma normal tissues from TCGA and 14 organ types with normal tissues from FANTOM5 CAGE were analyzed in order to explore and validate the expression of ACE2 on the mucosa of oral cavity. Further, single-cell transcriptomes from an independent data generated in-house were used to identify and confirm the ACE2-expressing cell composition and proportion in oral cavity. The results demonstrated that the ACE2 expressed on the mucosa of oral cavity. Interestingly, this receptor was highly enriched in epithelial cells of tongue. Preliminarily, those findings have explained the basic mechanism that the oral cavity is a potentially high risk for 2019-nCoV infectious susceptibility and provided a piece of evidence for the future prevention strategy in dental clinical practice as well as daily life.

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“…Hand-to-oral and hand-genital transmission has also been reported in earlier studies [62,63] but recent evidence for oral autoinoculation of the virus from anogenital sites is mixed. A recent study found an individual's genital HPV infection to be highly correlated with subclinical oral HPV infection [64], whereas others have not found concordance within the same patient [65,66].…”

Section: Hpv Transmission: "How When or From Whom Did I Get Hpv?"mentioning

confidence: 94%

A Patient-Centered Approach to Counseling Patients With Head and Neck Cancer Undergoing Human Papillomavirus Testing: A Clinician's Guide

et al. 2013

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Institute have acknowledged human papillomavirus (HPV)-16 as an independent risk factor for oropharyngeal cancer (OPC). HPV-positive oropharyngeal cancer (HPVOPC) is a sexually transmitted entity that is on the rise; within the next 10 years, the annual number of HPV-associated OPC cases is projected to exceed the annual number of cervical cancer cases in the United States. Recognition of HPV status in OPC has broad implications beyond the traditional oncological concerns of timely diagnosis, accurate staging, and appropriate treatment of cancer patients. The National Comprehensive Cancer Network recommends testing the tumor site for HPV-status during OPC management; it is likely this will become a standard component of care for patients with high-probability tumors of the oropharynx.As the practice of HPV testing becomes more common, it behooves providers to be able to adequately address the concerns of patients with HPVOPC. Although there are currently few relevant studies focusing on this population, existing literature on HPV-infected women and patients with cervical cancer strongly supports the concept that patients with HPVOPC need education to optimally address concerns such as selfblame, guilt, intimacy, and interpersonal relationships. When HPV testing is done, it should be accompanied by evidencedriven and patient-centered counseling to best minimize negative psychosocial outcomes and ensure optimum health promotion. Based on the current state of the literature, this article is intended to be a reference for physicians to effectively manage psychosocial outcomes when diagnosing patients with HPV-associated OPC. The Oncologist 2013;18:180 -189 Implications for Practice: HPV testing for individuals with high-probability tumors of the tonsil and base of tongue is an emerging standard of care. This article provides physicians with guidelines on how to provide optimal patient-centered counseling for individuals receiving the concurrent diagnoses of a sexually transmitted cancer, with the understanding that with HPV testing brings the responsibility for physicians to provide education, address patient concerns in an evidence-driven manner, screen for emotional distress, and make referrals to psychosocial care when needed.

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Asymptomatic oral human papillomavirus (HPV) infection in women with a histopathologic diagnosis of genital HPV

Cited by 19 publications

References 34 publications

Oral and cervical HPV infection in HIV‐positive and HIV‐negative women attending a sexual health clinic in São Paulo, Brazil

Oral and cervical HPV infection in HIV‐positive and HIV‐negative women attending a sexual health clinic in São Paulo, Brazil

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

A Patient-Centered Approach to Counseling Patients With Head and Neck Cancer Undergoing Human Papillomavirus Testing: A Clinician's Guide

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