Asymptomatic SARS-CoV-2 infection in Belgian long-term care facilities

Hoxha, Ana; Wyndham-Thomas, Chloé; Klamer, Sofieke; Dubourg, Dominique; Vermeulen, Melissa; Hammami, Naïma; Cornelissen, Laura

doi:10.1016/s1473-3099(20)30560-0

Cited by 53 publications

(64 citation statements)

References 3 publications

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“…Geographically we report evidence from eleven countries, the majority (20 studies) are from USA [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] and UK. [36][37][38][39][40] We report evidence from Canada, [41][42][43] France, 44,45 Hong Kong, 46,47 Belgium, 48 Germany, 49 Ireland, 50 Japan, 51 Korea, 52 and Spain 53 (Table 1).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Twenty studies report the nature of LTCFs related with outbreaks and transmission of COVID-19 infection (Table 2; 16,23,28,29,31,33,[35][36][37][38][39][41][42][43][45][46][47][50][51][52] ). Thirty studies (Table 3a; [17][18][19][20][21][22][23][24][25][26][27][28][29][32][33][34][37][38][39][40][41][42][43][45][46][47][48][49][50]53 ) report evidence of measures to ...…”

Section: Infection Control Measuresmentioning

confidence: 99%

“…A variety of infection control measures are described (Tables 1 and 3a-c) including: mass testing/point-prevalence testing (22 studies; 17,[19][20][21][22][25][26][27][28][29][30][32][33][34]38,39,44,45,[48][49][50]53 ), use of personal protective equipment (10 studies; 17,18,20,25,28,29,32,45,47,49 ), screening of residents, staff, or visitors for symptoms (8 studies; [18][19][20]23,25,27,29,32 ), restrictions on visitor entry (10 studies; [18][19][20]25,27,29,32,45,49,…”

Section: Infection Control Measuresmentioning

confidence: 99%

“…Morbidity and mortality results from included studies are presented for residents (Table 3a), staff (Table 3b), and visitors (Table 3c). Prevalence of COVID-19 infection was reported in 29 studies, including prevalence in residents (27 studies; [17][18][19][20][21][22][23][24][25][26][27][28][29][32][33][34]38,39,41,43,[45][46][47][48][49][50]53 ) and staff (22 studies; 17,[19][20][21][22]24,[26][27][28][29][30]32,34,38,39,[44][45][46][47][48]…”

Section: Morbidity and Mortalitymentioning

confidence: 99%

“…21 One study reported 16 COVID-19 positive visitor cases, 28 while a study which examined SARS infection following an outbreak in a Hong Kong facility reported 3 positive visitor cases. 47 The symptom status (symptomatic/presymptomatic/asymptomatic, typical/atypical symptoms) of participants was reported in 16 studies, with resident and staff symptom status reported in 15 [17][18][19]21,22,[25][26][27]29,32,33,45,48,50,53 and 13 studies, [19][20][21][22]26,27,29,32,44,45,48,50,53 respectively. No studies reported symptom status of visitors.…”

Section: Morbidity and Mortalitymentioning

confidence: 99%

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A rapid systematic review of measures to protect older people in long term care facilities from COVID-19

Frazer

Mitchell

Stokes

et al. 2020

Preprint

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The global COVID-19 pandemic produced large-scale health and economic complications. Older people and those with comorbidities are particularly vulnerable to this virus, with nursing homes and long term care facilities experiencing significant morbidity and mortality associated with COVID-19 outbreaks. The aim of this rapid systematic review was to investigate measures implemented in long term care facilities to reduce transmission of COVID-19 and their effect on morbidity and mortality of residents, staff, and visitors. Databases (including MedRXiv pre-published repository) were systematically searched to identify studies reporting assessment of interventions to reduce transmission of COVID-19 in nursing homes among residents, staff, or visitors. Outcome measures include facility characteristics, morbidity data, case fatalities, and transmission rates. Due to study quality and heterogeneity, no meta-analysis was conducted. The search yielded 1414 articles, with 38 studies included. Reported interventions include mass testing, use of personal protective equipment, symptom screening, visitor restrictions, hand hygiene and droplet/contact precautions, and resident cohorting. Prevalence rates ranged from 1.2-85.4% in residents and 0.6-62.6% in staff. Mortality rates ranged from 5.3-55.3% in residents. Novel evidence in this review details the impact of facility size, availability of staff and practices of operating between multiple facilities, and for-profit status of facilities as factors contributing to the size and number of COVID-19 outbreaks. No causative relationships can be determined; however, this review provides evidence of interventions that reduce transmission of COVID-19 in long term care facilities.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Infection Control Measuresmentioning

confidence: 99%

Section: Infection Control Measuresmentioning

confidence: 99%

Section: Morbidity and Mortalitymentioning

confidence: 99%

Section: Morbidity and Mortalitymentioning

confidence: 99%

See 3 more Smart Citations

A rapid systematic review of measures to protect older people in long term care facilities from COVID-19

Frazer

Mitchell

Stokes

et al. 2020

Preprint

View full text Add to dashboard Cite

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Global Percentage of Asymptomatic SARS-CoV-2 Infections Among the Tested Population and Individuals With Confirmed COVID-19 Diagnosis

et al. 2021

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Key Points Question What is the percentage of asymptomatic individuals with positive test results for SARS-CoV-2 among tested individuals and those with confirmed COVID-19 diagnosis? Findings In this systematic review and meta-analysis of 95 unique studies with 29 776 306 individuals undergoing testing, the pooled percentage of asymptomatic infections was 0.25% among the tested population and 40.50% among the population with confirmed COVID-19. Meaning The high percentage of asymptomatic infections from this study highlights the potential transmission risk of asymptomatic infections in communities.

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Comparison of the Characteristics of Asymptomatic and Presymptomatic Patients with Coronavirus Disease 2019 in the Republic of Korea

Hyun

Lee

Park

et al. 2021

J Epidemiol Glob Health

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Purpose This retrospective study aimed to evaluate the baseline characteristics of asymptomatic patients with coronavirus disease 2019 at admission and to follow-up their clinical manifestations and radiological findings during hospitalization. Methods Patients with coronavirus disease 2019 who were asymptomatic at admission were divided into two groups—those with no symptoms until discharge (group A) and those who developed symptoms after admission (group B). Patients who could not express their own symptoms were excluded. Results Overall, 127 patients were enrolled in the study, of whom 19 and 108 were assigned to groups A and B, respectively. The mean age and median C-reactive protein level were higher in group B than in group A. All patients in group A and one-third of patients in group B had normal initial chest radiographs; 15.8% and 48.1% of patients in groups A and B, respectively, had pneumonia during hospitalization. One patient in group B, whose condition was not severe at the time of admission, deteriorated due to aggravated pneumonia and was transferred to a tertiary hospital. Conclusion We summarize the clinical characteristics during hospitalization of patients with coronavirus disease 2019 who were purely asymptomatic at the time of admission. The majority of asymptomatic patients with coronavirus disease 2019 were discharged without significant events during hospitalization. However, it may be difficult to predict subsequent events from initial chest radiographs or oxygen saturation at admission.

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Asymptomatic SARS-CoV-2 infection in Belgian long-term care facilities

Cited by 53 publications

References 3 publications

A rapid systematic review of measures to protect older people in long term care facilities from COVID-19

A rapid systematic review of measures to protect older people in long term care facilities from COVID-19

Global Percentage of Asymptomatic SARS-CoV-2 Infections Among the Tested Population and Individuals With Confirmed COVID-19 Diagnosis

Comparison of the Characteristics of Asymptomatic and Presymptomatic Patients with Coronavirus Disease 2019 in the Republic of Korea

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