Asymptomatic Unconjugated Hyperbilirubinemia (Gilbert Syndrome) among Saudis in Jeddah

Bakhotmah, Mohamad Abid; Gasem, Abdulsalam Ali; Bairotee, Basim

doi:10.5144/0256-4947.1995.422

Cited by 8 publications

(9 citation statements)

References 7 publications

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“…We report a prevalence rate of 3.4% among individuals without T1DM. This rate concurs with reports from Chile, 16 Saudi-Arabia, 17 , and Singapore. 18 Among patients with T1DM, the prevalence of GS was 3-fold higher.…”

Section: Discussionsupporting

confidence: 91%

Gilbert syndrome in patients with type 1 diabetes-Prevalence, glycemic control, and microalbuminuria

2017

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Section: Discussionsupporting

confidence: 91%

Gilbert syndrome in patients with type 1 diabetes-Prevalence, glycemic control, and microalbuminuria

2017

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“…The condition is highly prevalent ranging from 3-12% of the population depending on the mode of diagnosis [1][2][3]. Intermittent jaundice is the only clinically recognised symptom, which can be triggered by infections, certain drugs and situations associated with low caloric intake such as gastrointestinal illness, surgery and fasting [4][5][6][7]. Some studies and patient information websites report that gastrointestinal symptoms and chronic fatigue are also symptoms [4,8,9] though this has not always been confirmed [10].…”

Section: Introductionmentioning

confidence: 99%

Gilbert's syndrome and the risk of death: A population‐based cohort study

Horsfall

Nazareth

Pereira

et al. 2013

J of Gastro and Hepatol

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Background and Aims Gilbert's syndrome is a common familial hyperbilirubinemia that may reduce the risk of various age‐related diseases because of the antioxidant properties of bilirubin. We conducted a large cohort study using The Health Improvement Network primary care database and compared all‐cause mortality rates in those with and without Gilbert's syndrome. Methods Mortality rates in patients with a diagnosis of Gilbert's syndrome and raised bilirubin level (n = 4266) were compared with those of patients with similar characteristics but with normal bilirubin levels (n = 21 968). Multivariate Poisson regression was also used to estimate adjusted mortality rate ratios. Results During the 350 000 PYs of follow up across the Gilbert's and comparison cohorts, there were 1174 deaths. Mortality rates were 24/10 000 PYs in the Gilbert's cohort versus 50/10 000 PYs in the comparison cohort. Mortality rates were around half in patients with Gilbert's syndrome after accounting for sociodemographics and general health indicators (adjusted mortality rate ratio: 0.5 [95% confidence interval; 0.4–0.7; P < 0.001]). Conclusions Mortality rates observed for people with Gilbert's syndrome in the general population are almost half those of people without evidence of Gilbert's syndrome.

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“…Usually, the diagnosis of Gilbert's syndrome is that of exclusion. Diagnosis may be confirmed by giving phenobarbital which relieves the jaundice and IV nicotinic acid which aggravates it [3].Any stress can aggravate the symptoms of Gilbert's syndrome e.g., fasting,surgery, infection, exercise, fatigue, alcohol intakeandmenstruation [4].…”

Section: Discussionmentioning

confidence: 99%

A case of Inherited Unconjugated Hyperbilirubinemia foran incidental surgery: Anesthetic management and Review

Namasivayam¹

2013

IOSR-JDMS

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Congenital indirecthyperbilirubinemiaoccurs due to the relative deficiency or absence of the primary conjugating enzyme uridinediphosphate-glucuronyltransferase.The enzyme UDP glucuronyltransferase is responsible for the conjugation of bilirubin in liver. The enzyme is also essential for transport of many other substrates including drugs, hormones, toxins and neurotransmitters. Thus, anaesthetic management of such a case is quite challenging. Avoiding drugs which use this enzyme for its metabolism or excretion during the perioperative period allows safe conduct of anaesthesia for these patients. We report a case of inherited unconjugated hyperbilirubinemiafor an incidental surgery and review the different types of congenital indirect hyperbilirubinemias.

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Asymptomatic Unconjugated Hyperbilirubinemia (Gilbert Syndrome) among Saudis in Jeddah

Cited by 8 publications

References 7 publications

Gilbert syndrome in patients with type 1 diabetes-Prevalence, glycemic control, and microalbuminuria

Gilbert syndrome in patients with type 1 diabetes-Prevalence, glycemic control, and microalbuminuria

Gilbert's syndrome and the risk of death: A population‐based cohort study

A case of Inherited Unconjugated Hyperbilirubinemia foran incidental surgery: Anesthetic management and Review

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