Abstract. Let (R, m, K) be a local ring, and let M be an R-module of finite length. We study asymptotic invariants, β F i (M, R), defined by twisting with Frobenius the free resolution of M . This family of invariants includes the Hilbert-Kunz multiplicity (e HK (m, R) = β F 0 (K, R)). We discuss several properties of these numbers that resemble the behavior of the Hilbert-Kunz multiplicity. Furthermore, we study when the vanishing of β F i (M, R) implies that M has finite projective dimension. In particular, we give a complete characterization of the vanishing of β F i (M, R) for one-dimensional rings. As a consequence of our methods, we give conditions for the non-existence of syzygies of finite length.