Abstract:We extend and refine recent results on Rényi entropy in two-dimensional conformal field theories at large central charge. To do so, we examine the effects of higher spin symmetry and of allowing unequal left and right central charges, at leading and subleading order in large total central charge. The result is a straightforward generalization of previously derived formulae, supported by both gravity and CFT arguments. The preceding statements pertain to CFTs in the ground state, or on a circle at unequal left-and right-moving temperatures. For the case of two short intervals in a CFT ground state, we derive certain universal contributions to Rényi and entanglement entropy from Virasoro primaries of arbitrary scaling weights, to leading and next-to-leading order in the interval size; this result applies to any CFT. When these primaries are higher spin currents, such terms are placed in one-to-one correspondence with terms in the bulk 1-loop determinants for higher spin gauge fields propagating on handlebody geometries.