Almost a century ago, Einstein used a weak field approximation around Minkowski space-time to calculate the energy carried away by gravitational waves emitted by a time changing mass-quadrupole. However, by now there is strong observational evidence for a positive cosmological constant, Λ. To incorporate this fact, Einstein's celebrated derivation is generalized by replacing Minkowski space-time with de Sitter space-time. The investigation is motivated by the fact that, because of the significant differences between the asymptotic structures of Minkowski and de Sitter space-times, many of the standard techniques, including the standard 1/r expansions, can not be used for Λ > 0. Furthermore since, e.g., the energy carried by gravitational waves is always positive in Minkowski space-time but can be arbitrarily negative in de Sitter space-time irrespective of how small Λ is, the limit Λ → 0 can fail to be continuous. Therefore, a priori it is not clear that a small Λ would introduce only negligible corrections to Einstein's formula. We show that, while even a tiny cosmological constant does introduce qualitatively new features, in the end, corrections to Einstein's formula are negligible for astrophysical sources currently under consideration by gravitational wave observatories.