At-home urine estrone-3-glucuronide quantification predicts oocyte retrieval outcomes comparably with serum estradiol

Nakhuda, Gary S.; Li, Ning; Yang, Zailin; Kang, Sylvia

doi:10.1016/j.xfre.2023.01.006

Cited by 5 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, urine E3G monitoring during gonadotropin stimulation has been found to be comparable with serum E2 for predicting oocyte retrieval outcomes when measured on the day of trigger with coefficients of determination of 0.7066 and 0.6102. Daily samples that were matched confirmed a good correlation between urine E3G and serum E2 [79].…”

Section: Ovarian Stimulationmentioning

confidence: 61%

“…There are practical examples of LFA utilization in stimulation cycles where urinary tests have shown rapid and accurate results that are comparable to blood ones [79]. For instance, urine E3G monitoring during gonadotropin stimulation has been found to be comparable with serum E2 for predicting oocyte retrieval outcomes when measured on the day of trigger with coefficients of determination of 0.7066 and 0.6102.…”

Section: Ovarian Stimulationmentioning

confidence: 99%

“…As LFAs showed great agreement in ovulation detection comparable to serum testing and ultrasound, they could be widely used in subfertile couples for timing intercourse, as well as in stimulation cycles where they showed comparable results in predicting oocyte retrieval outcomes [13,73,79] Conditions such as oligomenorrhea and amenorrhea can be present in women with primary ovarian insufficiency, hypothalamic amenorrhea and PCOS, making it important to distinguish the cause and establish a diagnosis. Physicians typically exclude pregnancy and then assess levels of FSH, LH, prolactin, androgens and TSH [48,56].…”

Section: Replacementmentioning

confidence: 99%

See 2 more Smart Citations

Gonadotropin and Ovarian Hormone Monitoring: Lateral Flow Assays for Clinical Decision Making

Targonskaya,

Maslowski

2023

Women

View full text Add to dashboard Cite

FSH, estrogen and progesterone testing are widely utilized in clinical practice. Lateral flow assays (LFAs) are cost-effective tools used for diagnosing infectious diseases, pregnancy, and substance testing. The focus of this narrative review is the potential for the wider utilization of listed hormone LFAs. A search was conducted with PubMed, Google Scholar and Wiley online libraries using keywords without any limitation on the publication date; animal studies were excluded. Clinical guidelines for the related conditions were included. According to published data, E3G and PdG are used to determine ovulatory cycles and can be utilized for research purposes to establish the normal range of menstrual cycles, as there is currently disagreement among guidelines. FSH measurement in blood samples is utilized to predict oocyte yield in assisted cycles and to differentiate women with premature ovarian insufficiency from hypothalamic amenorrhea, and can be replaced with more convenient urine testing. PdG was tested to assess the risk of pregnancy complications, specifically miscarriage and ectopic pregnancy, and might become a screening tool for miscarriage in the future. PMS, PMDD and ovarian carcinogenesis could be extensively studied using LFAs to gain a better understanding of the biology behind these conditions. Before implementing these LFAs into clinical practice, the reproducibility of progesterone assays should be evaluated. The results are critical for treatment decisions, and universally recognized standards for estradiol measurement should be developed.

show abstract

Section: Ovarian Stimulationmentioning

confidence: 61%

Section: Ovarian Stimulationmentioning

confidence: 99%

Section: Replacementmentioning

confidence: 99%

See 1 more Smart Citation

Gonadotropin and Ovarian Hormone Monitoring: Lateral Flow Assays for Clinical Decision Making

Targonskaya,

Maslowski

2023

Women

View full text Add to dashboard Cite

show abstract

“…Monitoring of the stimulation is based on the growth rate of E3G in the urine through its regular determination, independently by the patients in home conditions. The method is based on a relatively high correlation of estrone-3-glucuronide (E1-3G) urinary levels, which are a function of increasing estradiol levels during stimulation (24,25,26,27). The correlation was also established using the specific portable analyzer (4,10).…”

Section: Monitoring the Stimulationmentioning

confidence: 99%

A new method of Non-Ultrasound Monitoring of Ovarian Stimulation (NUMOS): Mission Possible! - a pilot study

Vladimirov,

Tacheva,

Gatev

et al. 2023

Preprint

View full text Add to dashboard Cite

Purpose: This study aims to establish the viability of monitoring an appropriate and safe ovarian stimulation without the use of ultrasound and serum hormone testing. Method: As a primary marker for monitoring of the ovarian response, we used urinary estrone-3-glucuronide (E1-3G) growth rate, which was self-measured by patients daily at home, with a portable analyzer, during the stimulation. For an adequate ovarian response, an average daily rate of increase of E1-3G was estimated to be within 25 - 77%. Ovulation trigger day was determined based on the length of the menstrual cycle. The study included 24 women. Inclusion criteria were age < 41 years and AMH >1 ng/mL. A progestin-primed ovarian stimulation protocol (PPOS) with fixed doses of gonadotropins was used. Results: The average female age was 32,9 years (±4.4), BMI 22,7 kg/m2 (±4,3), AMH 3,7 ng/ml (±2,6), stimulation days 10,6 (±1,1), collected oocytes 12,5 (±8,5), MII oocytes 10,6 (±7,8), fertilization rate 83,6% (±22,5), blastocyst 66,4% (±28,6), good quality blastocysts 31,6% (±16,9). Absence of oocyte aspiration was found in one of the cases. There were no cases of OHSS and ovarian stimulation cancellation. Conclusion: This is the first pilot study to successfully apply a new markers for ovarian stimulation monitoring.

show abstract

Editorial

Fischl

2023

J. Gynäkol. Endokrinol. AT

View full text Add to dashboard Cite

At-home urine estrone-3-glucuronide quantification predicts oocyte retrieval outcomes comparably with serum estradiol

Cited by 5 publications

References 26 publications

Gonadotropin and Ovarian Hormone Monitoring: Lateral Flow Assays for Clinical Decision Making

Gonadotropin and Ovarian Hormone Monitoring: Lateral Flow Assays for Clinical Decision Making

A new method of Non-Ultrasound Monitoring of Ovarian Stimulation (NUMOS): Mission Possible! - a pilot study

Editorial

Contact Info

Product

Resources

About