(AT)n is an interspersed repeat in the Xenopus genome.

Greaves, David R.; Patient, Roger

doi:10.1002/j.1460-2075.1985.tb03979.x

Cited by 38 publications

(13 citation statements)

References 93 publications

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“…Similar results have been obtained for the (AT)34 repeat from Xenopus that was discovered in the first intron of the tadpole CXTI globin gene [2].…”

Section: Discussionsupporting

confidence: 85%

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AT repeats in barley genome

Ermak¹,

Prosnyak²,

Vecher³

et al. 1990

FEBS Letters

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“…Similar results have been obtained for the (AT)34 repeat from Xenopus that was discovered in the first intron of the tadpole CXTI globin gene [2].…”

Section: Discussionsupporting

confidence: 85%

“…Simple sequence repeats have been found as interspersed elements in and around genes from different eukaryotic species [1,2]. There is a number of speculations concerning their role in genome.…”

Section: Introductionmentioning

confidence: 99%

AT repeats in barley genome

Ermak¹,

Prosnyak²,

Vecher³

et al. 1990

FEBS Letters

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“…The (TA)n sequence family has a low copy number and a dispersed distribution in the human genome (Greaves and Patient 1985). The (TC)n sequence family is present at 0.2% in the human genome (Tautz & Renz 1984).…”

Section: The Simple Sequence Families (Ta)~ (Tc)~ (Tg) (Gc)~mentioning

confidence: 99%

Potential genetic functions of tandem repeated DNA sequence blocks in the human genome are based on a highly conserved ?chromatin folding code?

Vogt¹

1990

Hum Genet

182

122

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This review is based on a thorough description of the structure and sequence organization of tandemly organized repetitive DNA sequence families in the human genome; it is aimed at revealing the locus-specific sequence organization of tandemly repetitive sequence structures as a highly conserved DNA sequence code. These repetitive so-called "super-structures" or "higher-order" structures are able to attract specific nuclear proteins. I shall define this code therefore as a "chromatin folding code". Since locus-specific superstructures of tandemly repetitive sequence units are present not only in the chromosome centromere or telomere region but also on the arms of the chromosomes, I assume that their chromatin folding code may contribute to, or even organize, the folding pathway of the chromatin chain in the nucleus. The "chromatin folding code" is based on its specific "chromatin code", which describes the sequence dependence of the helical pathway of the DNA primary sequence (i.e., secondary structure) entrapping the histone octamers in preferential positions. There is no periodicity in the distribution of the nucleosomes along the DNA chain. The folding pathway of the nucleosomal chromatin chain is however still flexible and determined by e.g., the length of the DNA chain between the nucleosomes. The fixation and stabilization of the chromatin chain in the space of the nucleus (i.e., its "functional state") may be mediated by additionally unique DNA protein interactions that are dictated by the "chromatin folding code". The unique DNA-protein interactions around the centromeres of human chromosomes are revealed for example by their "C-banding". I wish to stress that it is not my aim to relate each block of repetitive DNA sequences to a specific "chromatin folding code", but I shall demonstrate that there is an inherent potential for tandem repeated sequence units to develop a locus-specific repetitive higher order structure; this potential may create a specific chromatin folding code whenever a selection force exists at the position of this repetitive DNA structure in the genome.

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“…Repetitive tracts of certain short base motifs, termed "simple DNA," are widely distributed in inter-and intraPreseented at the NATO Advanced Research Workshop on Genorne Organization and Evolution, Spetsai, Greece, 16-22 September 1992 genic regions (Tautz and Rentz 1984;Greaves and Patient 1985;Tautz et al 1986;Epplen 1988;Beckmann and Weber 1992). In this presentation we shall be concerned with a related class of simple DNA---namely, with tracts composed of only two of the four bases.…”

Section: Introductionmentioning

confidence: 98%

The frequency of two-base tracts in eukaryotic genomes

Yagil

1993

J Mol Evol

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The frequency of two-base tracts is surveyed in a wide range of eukaryotic genomes using the special program TRACTS. All three two-base families are surveyed: R.Y (A,G.C,T), K.M (A,C.G,T), and S;W (A.T and G.C). Data for the human beta-globin complex, for the tobacco chloroplast, and for 247 nt mammalian promoter regions are presented. All two-base tracts longer than three or four bases are overrepresented to an extent surpassing by far their occurrence in a randomized DNA population in the majority of the genomic regions analyzed; 20-30 long tracts are quite frequent, against the statistical odds. R.Y tracts are found at the largest excess, K.M tract to a slightly lesser extent, while S.W tracts are found at a moderate yet significant excess. The majority of the tracts manifest only a limited extent of tandem repeat structures. The idea that the two base tracts serve as unwinding elements is considered.

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(AT)n is an interspersed repeat in the Xenopus genome.

Cited by 38 publications

References 93 publications

AT repeats in barley genome

AT repeats in barley genome

Potential genetic functions of tandem repeated DNA sequence blocks in the human genome are based on a highly conserved ?chromatin folding code?

The frequency of two-base tracts in eukaryotic genomes

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