At the heart of microbial conversations: endocannabinoids and the microbiome in cardiometabolic risk

Khan, Ramsha; Maner-Smith, Kristal; Owens, Joshua; Barbian, Maria E.; Naudin, Crystal

doi:10.1080/19490976.2021.1911572

Cited by 16 publications

(5 citation statements)

References 162 publications

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“…An intercommunication system has been found to exist between the gut microbiota and the endocannabinoid system [285,298,[397][398][399][400][401][402]. The gut microbiota, representing more than 100 trillion microorganisms, including at least 1000 distinct species, lives in symbiosis with the host and assists in controlling the metabolic health of the host by degrading nutrients that the host is unable to digest and by providing a whole battery of small signaling molecules, metabolites, and nutrients beneficial for the host physiology [298,403].…”

Section: Dialog Between the Gut Microbiota And The Endocannabinoid Sy...mentioning

confidence: 99%

Anti-Microbial Activity of Phytocannabinoids and Endocannabinoids in the Light of Their Physiological and Pathophysiological Roles

Sionov

Steinberg

2022

Biomedicines

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Antibiotic resistance has become an increasing challenge in the treatment of various infectious diseases, especially those associated with biofilm formation on biotic and abiotic materials. There is an urgent need for new treatment protocols that can also target biofilm-embedded bacteria. Many secondary metabolites of plants possess anti-bacterial activities, and especially the phytocannabinoids of the Cannabis sativa L. varieties have reached a renaissance and attracted much attention for their anti-microbial and anti-biofilm activities at concentrations below the cytotoxic threshold on normal mammalian cells. Accordingly, many synthetic cannabinoids have been designed with the intention to increase the specificity and selectivity of the compounds. The structurally unrelated endocannabinoids have also been found to have anti-microbial and anti-biofilm activities. Recent data suggest for a mutual communication between the endocannabinoid system and the gut microbiota. The present review focuses on the anti-microbial activities of phytocannabinoids and endocannabinoids integrated with some selected issues of their many physiological and pharmacological activities.

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Section: Dialog Between the Gut Microbiota And The Endocannabinoid Sy...mentioning

confidence: 99%

Anti-Microbial Activity of Phytocannabinoids and Endocannabinoids in the Light of Their Physiological and Pathophysiological Roles

Sionov

Steinberg

2022

Biomedicines

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“…It is reported that 95% of diseases are related to gut microbiota. In addition to gastrointestinal diseases, metabolic diseases, gut microbiota is also related to various system diseases, such as nervous system ( Vicentini et al., 2021 ; Saldana-Morales et al., 2021 ), respiratory system ( Zheng et al., 2020 ; Casaro et al., 2021 ), cardiovascular system ( Khan et al., 2021 ; Deng et al., 2022 ), tumor ( Yang et al., 2020 ; Chung et al., 2021 ; Murphy et al., 2021 ), etc. disease related.…”

Section: Gut Microbiomementioning

confidence: 99%

Association of Gut Microbiota With Intestinal Ischemia/Reperfusion Injury

Chen

Wang

Shi

et al. 2022

Front. Cell. Infect. Microbiol.

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Intestinal ischemia/reperfusion (II/R) is a common acute and critical condition in clinical practice with a high mortality rate. However, there is still a lack of effective prevention and treatment measures for II/R injury. The role of the gut microbiota in II/R has attracted widespread attention. Recent evidence has demonstrated that the gut microbiota plays a pivotal role in the occurrence, development, and prognosis of II/R. Therefore, maintaining the homeostasis of gut microbiota and its metabolites may be a potential strategy for the treatment of II/R. This review focuses on the importance of crosstalk between the gastrointestinal ecosystem and II/R to highlight II/R-induced gut microbiota signatures and potential applications of microbial-based therapies in II/R. This will also provide potentially effective biomarkers for the prediction, diagnosis and treatment of II/R.

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“…Interestingly, in various aging associated cardiovascular diseases such as obesity, diabetes, and hypertension, dysregulation of the ECS signaling was shown to play pivotal roles. Moreover, a decreased plasma levels of 2-AG and AEA is associated with the alteration of cannabinoid receptor expression in the vasculature, suggesting that the ECS may represent a promising complementary therapeutic approach for the treatment of aging associated cardiovascular diseases [ 374 , 375 , 376 , 377 , 378 ]. We will further focus on describing the relationship between the ECS modulation and the physiopathology of the two most prevalent risk factor for CVDs associated with aging: arterial hypertension and atherosclerosis.…”

Section: Cardiovascular Aging and Cannabinoid Systemmentioning

confidence: 99%

The Therapeutic Potential of the Endocannabinoid System in Age-Related Diseases

et al. 2022

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The endocannabinoid system (ECS) dynamically regulates many aspects of mammalian physiology. ECS has gained substantial interest since growing evidence suggests that it also plays a major role in several pathophysiological conditions due to its ability to modulate various underlying mechanisms. Furthermore, cannabinoids, as components of the cannabinoid system (CS), have proven beneficial effects such as anti-inflammatory, immunomodulatory, neuromodulatory, antioxidative, and cardioprotective effects. In this comprehensive review, we aimed to describe the complex interaction between CS and most common age-related diseases such as neuro-degenerative, oncological, skeletal, and cardiovascular disorders, together with the potential of various cannabinoids to ameliorate the progression of these disorders. Since chronic inflammation is postulated as the pillar of all the above-mentioned medical conditions, we also discuss in this paper the potential of CS to ameliorate aging-associated immune system dysregulation.

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At the heart of microbial conversations: endocannabinoids and the microbiome in cardiometabolic risk

Cited by 16 publications

References 162 publications

Anti-Microbial Activity of Phytocannabinoids and Endocannabinoids in the Light of Their Physiological and Pathophysiological Roles

Anti-Microbial Activity of Phytocannabinoids and Endocannabinoids in the Light of Their Physiological and Pathophysiological Roles

Association of Gut Microbiota With Intestinal Ischemia/Reperfusion Injury

The Therapeutic Potential of the Endocannabinoid System in Age-Related Diseases

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