AT1 receptor heterodimers and angiotensin II responsiveness in preeclampsia

Quitterer, Ursula; Lother, Heinz; AbdAlla, Said

doi:10.1016/j.semnephrol.2003.11.007

Cited by 50 publications

(47 citation statements)

References 45 publications

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“…The intriguing formation of angiotensin 1 receptor (AT1R) and bradykinin 2 receptor (B2R) heteromers were implicated in the pathophysiological development of pre-eclampsia (47,48). The expression of AT1R-B2R heteromers were more abundant on platelets and omental vessels isolated from women with preeclampsia, with increased heteromer formation due to the upregulated expression of B2R, resulting in the elevation of angiotensin II-dependent Gq activity.…”

Section: Reproductionmentioning

confidence: 99%

Impact of G protein-coupled receptor heteromers in endocrine systems

Jonas

Hanyaloglu

2017

Molecular and Cellular Endocrinology

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Abbreviations:1B adrenergic receptors (1BR) Evidence over the last 20 years has highlighted homo and heteromerization as a key mode of mediating GPCR functional diversity. This review will discuss the concept of GPCR heteromerization and its relevance to endocrine function, detailing in vitro and in vivo evidence, and exploring current and potential pharmacological strategies for specific targeting of GPCR heteromers in endocrine heath and disease.;3

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Section: Reproductionmentioning

confidence: 99%

Impact of G protein-coupled receptor heteromers in endocrine systems

Jonas

Hanyaloglu

2017

Molecular and Cellular Endocrinology

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“…This implies that there is a dysfunction of salt-water balance that is dominated mainly by ALD. Moreover, compared with the increase in RAAS components in normotensive pregnancy, the circulating levels of renin, ANG I, ANG II, ANG (1-7), and ALD are much lower, yet with little fluctuation of ACE levels (Granger et al 2001, Merrill et al 2002; stranger still, there is a relatively higher level of ALD for the given level of renin (Gallery & Brown 1987) and worse, pregnant women are highly sensitive to the pressor effects of ANG II partly due to heterodimerization of AT1R (Quitterer et al 2004, Abdalla et al 2005. As for local uteroplacental RAS, there are some various and controversial results: recently, Herse et al (2007) argued that excessive expression of the AT1R receptor in maternal deciduas is the only change observed in local RAS, without any increase in renin production in decidua of preeclamptic patients.…”

Section: Changes In Both Circulating Raas and Local Ras During Preeclmentioning

confidence: 99%

The role of the renin–angiotensin–aldosterone system in preeclampsia: genetic polymorphisms and microRNA

Yang¹,

Shang²,

Zhang³

et al. 2013

Journal of Molecular Endocrinology

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The compensatory alterations in the rennin-angiotensin-aldosterone system (RAAS) contribute to the salt-water balance and sufficient placental perfusion for the subsequent well-being of the mother and fetus during normal pregnancy and is characterized by an increase in almost all the components of RAAS. Preeclampsia, however, breaks homeostasis and leads to a disturbance of this delicate equilibrium in RAAS both for circulation and the uteroplacental unit. Despite being a major cause for maternal and neonatal morbidity and mortality, the pathogenesis of preeclampsia remains elusive, where RAAS has been long considered to be involved. Epidemiological studies have indicated that preeclampsia is a multifactorial disease with a strong familial predisposition regardless of variations in ethnic, socioeconomic, and geographic features. The heritable allelic variations, especially the genetic polymorphisms in RAAS, could be the foundation for the genetics of preeclampsia and hence are related to the development of preeclampsia. Furthermore, at a posttranscriptional level, miRNA can interact with the targeted site within the 3 0 -UTR of the RAAS gene and thereby might participate in the regulation of RAAS and the pathology of preeclampsia. In this review, we discuss the recent achievements of genetic polymorphisms, as well as the interactions between maternal and fetal genotypes, and miRNA posttranscriptional regulation associated with RAAS in preeclampsia. The results are controversial but utterly inspiring and attractive in terms of potential prognostic significance. Although many studies suggest positive associations with genetic mutations and increased risk for preeclampsia, more meticulously designed large-scale investigations are needed to avoid the interference from different variations.

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“…However, many clinical trials suggest alterations in renin-angiotensin system (RAS) components in the pathogenesis of preeclampsia. [2][3][4] The regulation of the RAS in preeclampsia differs from that in healthy pregnancies. Although most circulating RAS components increase in an uncomplicated pregnancy, preeclamptic women have lower circulating levels of RAS components than normotensive pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Association between urinary angiotensinogen, hypertension and proteinuria in pregnant women with preeclampsia

Yılmaz

Yıldırım

Yılmaz

et al. 2014

J Renin Angiotensin Aldosterone Syst

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Introduction: Preeclampsia is a life-threatening disorder of pregnancy. The pathogenic mechanisms of preeclampsia remain uncertain. The aim of this study is to investigate the relation between urinary angiotensinogen (UAGT) levels, an indicator of local renin-angiotensin system (RAS) activity in the kidney, and blood pressure and urinary protein excretion in preeclampsia. Materials and methods: For this study, 90 women aged between 20-39 years were recruited. Spot urine samples were collected to measure urinary angiotensinogen/creatinine ratio (UAGT/UCre). Log(UAGT/UCre) was compared in pregnancies with and without preeclampsia and non-pregnant controls. Factors affecting log(UAGT/UCre) in pregnancies were also investigated. Results: In all pregnancies log(UAGT/UCre) levels were significantly higher than in non-pregnant controls (0.58±0.19 vs. 0.33±0.14, respectively, p=0.002). However, log(UAGT/UCre) levels in pregnancies with preeclampsia were slightly lower than in normal pregnancies (0.52±0.18 vs. 0.64±0.19, respectively, p=0.012). Log(UAGT/UCre) levels were correlated positively with blood pressure and proteinuria in pregnancies with preeclampsia. However, log(UAGT/UCre) levels were not correlated with age, height, body weight, gestational age, body mass index, and serum creatinine. Conclusion: This study showed that elevated local RAS activity in kidney was correlated with high blood pressure and proteinuria in preeclampsia. Local RAS activation in the kidneys may be one of the contributing factors in the development of preeclampsia.

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AT1 receptor heterodimers and angiotensin II responsiveness in preeclampsia

Cited by 50 publications

References 45 publications

Impact of G protein-coupled receptor heteromers in endocrine systems

Impact of G protein-coupled receptor heteromers in endocrine systems

The role of the renin–angiotensin–aldosterone system in preeclampsia: genetic polymorphisms and microRNA

Association between urinary angiotensinogen, hypertension and proteinuria in pregnant women with preeclampsia

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