AT1 Receptors Prevent Salt-Induced Vascular Dysfunction in Isolated Middle Cerebral Arteries of 2 Kidney-1 Clip Hypertensive Rats

Abstract

background Elevated blood pressure, elevated angiotensin II (ANG II), and ANG II suppression with high salt (HS) diet all contribute to vascular dysfunction. This study investigated the interplay of HS diet and vascular function in a high renin model of hypertension.

Response to “Does Angiotensin-Dependent Superoxide Production Help to Prevent Salt-Induced Endothelial Dysfunction in 2 Kidney–1 Clip Hypertensive Rats?”

“…To the Editor: We recently reported the surprising finding that the salt-induced endothelial dysfunction and downregulation of copper (Cu)/zinc (Zn) superoxide dismutase (SOD) that occurred in cerebral arteries of sham-operated animals were absent in 2 kidney-1 clip (2K1C) hypertensive rats, which exhibit prolonged elevations of plasma angiotensin II (ANG II) levels, and that AT 1 receptor blockade with losartan eliminated endothelium-dependent vasodilation in 2K1C rats. 1 We concluded that the elevated ANG II levels in the 2K1C rats played a key role in protecting against salt-induced vascular dysfunction and suppression of Cu/Zn SOD by upregulating antioxidant defense mechanisms in the arteries.…”

Meta-Analysis of Dependence of the Development of Experimental Renovascular Hypertension “2 Kidneys, 1 Clamp” on Lifestyle Factors

“…При поиске по ключевым словам (NaCl, renovascular hypertension, rats) было найдено в базах 53 публикации (из них 6 обзоров литературы). После исключения статей по заголовкам, резюме, а также повторных публикаций для метаанализа было отобрано 9 публикаций [18][19][20][21][22][23][24][25][26], в которых сравнивалась величина подъема АД после стенозирования почечной артерии у крыс, содержащихся на стандартной диете и высокосолевой диете. В 8 публикациях оценивалось влияние диеты на АРП.…”

Vaccarin administration ameliorates hypertension and cardiovascular remodeling in renovascular hypertensive rats

“…Angiotensin (Ang) II is known to be one of biological active peptides of RAS, which exerts a fundamental role in sympathetic outflow and cardiovascular activity . The plasma renin, Ang II, and Ang II type 1 receptors (AT1R) in myocardium and ascending aorta are enhanced in animals with hypertensive models . Among a wide range of experimental or genetic models of hypertension, 2K1C hypertensive model is believed to be renovascular Ang II‐dependent hypertension, the transient activation of RAS contributes to the sustained increase in blood pressure …”

“…11 The plasma renin, Ang II, and Ang II type 1 receptors (AT1R) in myocardium and ascending aorta are enhanced in animals with hypertensive models. [12][13][14] Among a wide range of experimental or genetic models of hypertension, 2K1C hypertensive model is believed to be renovascular Ang II-dependent hypertension, the transient activation of RAS contributes to the sustained increase in blood pressure. 11,15 Complementary therapies are popular in recent years, and they are considered as promising strategies for the prevention and treatment of cardiovascular disorders including hypertension.…”