Ataxin-2 is essential for cytoskeletal dynamics and neurodevelopment in Drosophila

Castillo, Urko del; Norkett, Rosalind; Lü, Wen; Serpinskaya, Anna S.; Gelfand, Vladimir I.

doi:10.1016/j.isci.2021.103536

Cited by 5 publications

(1 citation statement)

References 73 publications

(110 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…and Ataxin proteins (Q99700 and Q8WWM7) which mediate actin stabilisation [30]. We investigated the extent to which LCRs featured in our hunt for molecular mimics and whether they confounded our results (Figure 8).…”

Section: Mhr-containing Proteinsmentioning

confidence: 99%

Identification of potential molecular mimicry in pathogen-host interactions

Rich

Srivastava

Muthye

et al. 2023

Preprint

View full text Add to dashboard Cite

Pathogens have evolved sophisticated strategies to manipulate host signaling pathways, including the phenomenon of molecular mimicry, where pathogen-derived biomolecules imitate host biomolecules. In this study, we used a sequence-based bioinformatics pipeline to identify potential molecular mimicry candidates between humans and 32 pathogenic species-bacteria, fungi, protozoa, and helminths-of global health importance. We observed considerable variation in the number of mimicry candidates across pathogenic species, with pathogenic bacteria exhibiting fewer candidates compared to fungi and protozoans. Further analysis revealed that the candidate mimicry regions were enriched in solvent-accessible regions, highlighting their potential functional relevance. We identified a total of 1878 mimicked regions in 1439 human proteins, and clustering analysis indicated diverse target proteins across pathogen species. The human proteins containing mimicked regions revealed significant associations between these proteins and various biological processes, with an emphasis on host extracellular matrix organization and cytoskeletal processes. However, immune-related proteins were underrepresented as targets of mimicry. Our findings provide insights into the broad range of host-pathogen interactions mediated by molecular mimicry and highlight potential targets for further investigation. This comprehensive analysis contributes to our understanding of the complex mechanisms employed by pathogens to subvert host defenses and promotes the development of novel therapeutic strategies.

show abstract

Section: Mhr-containing Proteinsmentioning

confidence: 99%

Identification of potential molecular mimicry in pathogen-host interactions

Rich

Srivastava

Muthye

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Ataxin-2: a powerful RNA-binding protein

Li,

Wang,

Huang

et al. 2024

Discov Onc

View full text Add to dashboard Cite

Ataxin-2 (ATXN2) was originally discovered in the context of spinocerebellar ataxia type 2 (SCA2), but it has become a key player in various neurodegenerative diseases. This review delves into the multifaceted roles of ATXN2 in human diseases, revealing its diverse molecular and cellular pathways. The impact of ATXN2 on diseases extends beyond functional outcomes; it mainly interacts with various RNA-binding proteins (RBPs) to regulate different stages of post-transcriptional gene expression in diseases. With the progress of research, ATXN2 has also been found to play an important role in the development of various cancers, including breast cancer, gastric cancer, pancreatic cancer, colon cancer, and esophageal cancer. This comprehensive exploration underscores the crucial role of ATXN2 in the pathogenesis of diseases and warrants further investigation by the scientific community. By reviewing the latest discoveries on the regulatory functions of ATXN2 in diseases, this article helps us understand the complex molecular mechanisms of a series of human diseases related to this intriguing protein.

show abstract