Atazanavir-Associated Crystalline Nephropathy

Santoriello, Dominick; AlNabulsi, M.; Reddy, Aravinda; Salamera, Julius; D’Agati, Vivette D.; Markowitz, Glen S.

doi:10.1053/j.ajkd.2017.02.376

Cited by 16 publications

(15 citation statements)

References 19 publications

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“…Interestingly, in our study, we found lower baseline eGFR, nadir CD4 counts, uncontrolled viremia, and current PI/r use associated with incident CKD. Although we did not have adequate power to determine which PI/r was associated with CKD, previous analyses have indicated that ATV causes nephrolithiasis and is associated with development of interstitial nephritis, switching from ATV/r or LPV/r to DRV/r is associated with improvement in kidney function, and use of a concomitant PI/r with TDF amplifies the renal toxicity of the later due to inhibition of Multi‐resistant Protein 4 (MRP‐4) efflux channels in the proximal tubular cells by ritonavir leading to TDF accumulation in the cells …”

Section: Discussionmentioning

confidence: 99%

Changes in renal function with long‐term exposure to antiretroviral therapy in HIV‐infected adults in Asia

Joshi¹,

Boettiger

Kerr

et al. 2018

Pharmacoepidemiology and Drug

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Introduction: Renal disease is common amongst people living with HIV. However, there is limited information on the incidence and risk factors associated with renal dysfunction among this population in Asia. Methods: We used data from the TREAT Asia HIV Observational Database. Patients were included if they started antiretroviral therapy (ART) during or after 2003, had a serum creatinine measurement at ART initiation (baseline) and had at least two follow-up creatinine measurements taken ≥3 months apart. Patients with a baseline estimated glomerular filtration rate (eGFR) ≤60ml/min/1.73m2 were excluded. Chronic kidney disease was defined as two consecutive eGFR values ≤60ml/min/1.73m2 taken ≥3 months apart. Generalized estimating equations were used to identify factors associated with eGFR change. Competing risk regression adjusted for study site, age and sex, and cumulative_incidence plots were used to evaluate factors associated with CKD. Results: Of 2,547 patients eligible for this analysis, tenofovir was being used by 703 (27.6%) at baseline. Tenofovir use, high baseline eGFR, advanced HIV disease stage and low nadir CD4 were associated with a decrease in eGFR during follow up. CKD occurred at a rate of 3.4 per 1000 patient/years. Factors associated with CKD were tenofovir use, old age, low baseline eGFR, low nadir CD4, and protease inhibitor use. Conclusions: There is an urgent need to enhance renal monitoring and management capacity among at-risk groups in Asia and improve access to less nephrotoxic antiretrovirals.

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Section: Discussionmentioning

confidence: 99%

Changes in renal function with long‐term exposure to antiretroviral therapy in HIV‐infected adults in Asia

Joshi¹,

Boettiger

Kerr

et al. 2018

Pharmacoepidemiology and Drug

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“…The dysproteinemia-related CN includes light chain cast nephropathy, also known as myeloma cast nephropathy, which is the most common dysproteinemia-related renal disease [53,54]. Crystalline nephropathy may develop during the use of drugs (ceftriaxone [55]), sulfadiazine [56], acyclovir [57], triamterene [58], atanazavir [59], and others that are excreted by the kidney (see details in recent review [60]). Calcium crystals CN is characterized by abundant tubular and interstitial deposits of calcium phosphate or CaOx crystals, easily distinguished by their tinctorial properties.…”

Section: Determinants Of Randall's Plaque Formationmentioning

confidence: 99%

Meeting report of the “Symposium on kidney stones and mineral metabolism: calcium kidney stones in 2017”

et al. 2019

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A symposium on kidney stones and mineral metabolism held on December 2017 in Brussels, Belgium was the first international multidisciplinary conference of the International Collaborative Network on Kidney Stones and Mineral Metabolism. This meeting addressed epidemiology, underlying pathophysiological mechanisms, genetics, pathological, as well as clinical and research topics. The participants included clinicians and recognized experts in the field from Europe and the United States interacted closely during the symposium which promoted a chance to explore new frontiers in the field of kidney stone disease. This manuscript summarizes some of the major highlights of the meeting.

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“…Whether these genetic polymorphisms also increase risk for crystalline nephropathy is unknown. Protease inhibitor-induced crystalline nephropathy is more likely to occur in the setting of volume depletion, excessive drug dosing, low body weight, underlying liver disease, and alkaline urine (1)(2)(3)(4)(22)(23)(24)(25)(26)(27). Darunavir has also been associated with crystalluria, nephrolithiasis, and crystalline nephropathy (24).…”

Section: Protease Inhibitors (Indinavir Atazanavir and Darunavir)mentioning

confidence: 99%

“…Boosting with ritonavir further increases risk for darunavir-related intratubular crystal formation (24). In addition to ritonavir, darunavir has similar risk factors for crystalline nephropathy and nephrolithiasis (1)(2)(3)(4)(22)(23)(24)(25)(26)(27).…”

Section: Protease Inhibitors (Indinavir Atazanavir and Darunavir)mentioning

confidence: 99%

The Crystalline Nephropathies

Perazella

Herlitz

2021

Kidney International Reports

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Atazanavir-Associated Crystalline Nephropathy

Cited by 16 publications

References 19 publications

Changes in renal function with long‐term exposure to antiretroviral therapy in HIV‐infected adults in Asia

Changes in renal function with long‐term exposure to antiretroviral therapy in HIV‐infected adults in Asia

Meeting report of the “Symposium on kidney stones and mineral metabolism: calcium kidney stones in 2017”

The Crystalline Nephropathies

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