Atención del stroke agudo en una unidad de stroke y una sala general

Rodríguez, Gabriel; González, Leonardo; Luraschi, A.; Melamud, Luciana; Lepera, Sandra; Rey, R.

doi:10.1016/s0325-0938(10)70003-9

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…The temporal and reversive opening of the BBB would permit less invasive and more effective drug-based therapies for neurological disorders such as PD [ 6 ]. The tight junction of endothelial cells that form the BBB impedes the passage of nearly 100% of molecules to the brain, including neurotherapeutic drugs [ 6 , 7 , 8 ]. Invasive techniques, such as a direct injection in the brain, provide the drugs to the target site, bypassing the BBB, but these invasive techniques are capable of producing irreversible damage to the brain and patient [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Protocol to Induce the Temporary Opening of the Blood–Brain Barrier with Short-Time Focused Ultrasound in Rats

Rodríguez,

Gutiérrez,

Vera

et al. 2023

Pharmaceutics

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Brain neurodegenerative diseases are central nervous system (CNS) affections typically common in older adults. A new therapeutic approach for them consists of providing specific drugs to the CNS through blood circulation; however, the Blood–Brain Barrier (BBB) prevents almost 100% of neurotherapeutics from reaching the brain. There are indications that Focused Ultrasound (FUS), temporarily placed in the BBB, can achieve a controlled increase in temperature at its focus, allowing temporary, localized, and reversible opening of this barrier, which facilitates the temporary delivery of specific drugs. This work presents a FUS-based protocol for the local, temporary, and reversible opening of the BBB in Wistar rats. The proposed protocol specifies certain power, treatment times, and duty cycle to controllably increase the temperature at the region of interest, i.e., the substantia nigra. Numerical simulations using commercial software based on the finite element method were carried out to determine the optimal size of the craniotomies for nearly full-acoustic transmission. Experiments in rats were performed with the parameters used during computational simulations to determine the adequate opening of the BBB. For this, craniotomies of different sizes were made at coordinates of the substantia nigra, and FUS was applied from the exterior. The opening of the BBB was evaluated using Evans Blue (EB) as an indicator of the crossing of the dye from the blood vessels to brain tissue. Numerical simulations demonstrated a major distance reached by the ultrasound focus with a bigger diameter. Experimental results show the local, temporary, and reversible opening of the BBB through a 10 mm diameter craniotomy, which effectively allowed placing the ultrasound focus over the substantia nigra, unlike a 6 mm diameter craniotomy in which there is a deviation of the focus through that window. Moreover, from these results, it was also determined that the disruption of the BBB was reversible, with an opening duration of 6 h after FUS application. The experimental work developed in this study resulted in a minimally invasive method for the temporary opening of the BBB.

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Section: Introductionmentioning

confidence: 99%

Protocol to Induce the Temporary Opening of the Blood–Brain Barrier with Short-Time Focused Ultrasound in Rats

Rodríguez,

Gutiérrez,

Vera

et al. 2023

Pharmaceutics

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“…De hecho, a pesar de contar con una recomendación sólida a nivel mundial y nacional por parte de diferentes organizaciones científicas, no existe en Argentina ninguna exigencia de estas unidades en centros de alta complejidad por parte del estado. Sin embargo, en Buenos Aires, la presencia de una UACV en un hospital público ha mostrado que reduce significativamente los días de internación de los pacientes (promedio 7 vs. 23 días, p = 0.001) 16 .…”

Section: Situación Epidemiológica Del Accidente Cerebro Vascular Isquémico En Argentinaunclassified

Construção de vídeo instrucional para a regulação de vaga do acidente vascular cerebral fase hiperaguda.

Santos

Fontes

Ferreira

et al. 2021

Com. Ciências Saúde

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Objetivo: Elaborar um vídeo instrucional sobre o processo de regulação de vagas. Métodos: Foi utilizado a produção de roteiro de imagens e gravação de áudio com os softwares: Pixton®; Adobe Photoshop®; Camtasia®; Powtoon®. Resultados: o vídeo contém orientações de preenchimento da ficha de regulação para capacitação profissional para otimizar o tempo, beneficiar o tratamento e diminuir sequelas, garantindo o acesso à assistência especializada. Conclusões: O vídeo instrucional produzido pode colaborar na educação em serviço de profissionais que atuam em núcleos de regulação de vagas de acordo com a linha de cuidado do AVC hiperagudo e em unidades solicitantes.

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“…Cerebrovascular diseases (CVDs), as well as their sequelae, are the world's leading cause of disability with more than five million people affected worldwide annually 9,10 . In patients with stroke sequelae, negative changes in their sexual life have been described 11 .…”

Section: Introductionmentioning

confidence: 99%

Everything you always wanted to know about sex and Neurology: neurological disability and sexuality

Nasimbera

Rosales

Silva

et al. 2018

Arq. Neuro-Psiquiatr.

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Disability proved to be the main variable related to the presence of sexual dysfunction. Patients with ALS had the worst rates of sexual dysfunction. Patients with MS were similar to the control group. As for the PD group, no patient had normal sexuality. Finally, in stroke patients, the presence of comorbidities and their treatment may have negatively influenced sexuality. These findings showed that patients with chronic neurological diseases have sexual dysfunction and underscore the need for neurologists to know and address this problem.

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Atención del stroke agudo en una unidad de stroke y una sala general

Cited by 5 publications

References 17 publications

Protocol to Induce the Temporary Opening of the Blood–Brain Barrier with Short-Time Focused Ultrasound in Rats

Protocol to Induce the Temporary Opening of the Blood–Brain Barrier with Short-Time Focused Ultrasound in Rats

Construção de vídeo instrucional para a regulação de vaga do acidente vascular cerebral fase hiperaguda.

Everything you always wanted to know about sex and Neurology: neurological disability and sexuality

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