Aterosclerosis placentaria y marcadores de disfunción endotelial en neonatos hijos de madres con diabetes gestacional

Morales, Cruz Mónica López; Zurita, Olga; Heredia, Ricardo González; López, Miguel Cruz; Padrón, Araceli Méndez; Briseño, Juan Antonio Matute

doi:10.1016/j.medcli.2016.03.031

Cited by 9 publications

(4 citation statements)

References 25 publications

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“…Bugatto et al found that the mean uterine artery Doppler pulsatility index in patients with GDM was significantly positively correlated with IL-6, triglycerides and glycated hemoglobin, implying that alterations in lipids and glycemic homeostasis are associated with vascular pathologies [ 128 ]. For instance, placental atherosclerosis was discovered significantly more often in patients with GDM compared with normal pregnancies [ 143 ]. Hence, carotid artery intima-media thickness (IMT) measurement is used to assess subclinical atherosclerosis and predict the risk of future adverse cardiovascular events in asymptomatic patients [ 144 ].…”

Section: Discussionmentioning

confidence: 99%

Endothelial Dysfunction in Pregnancy Complications

et al. 2021

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The endothelium, which constitutes the inner layer of blood vessels and lymphatic structures, plays an important role in various physiological functions. Alterations in structure, integrity and function of the endothelial layer during pregnancy have been associated with numerous gestational complications, including clinically significant disorders, such as preeclampsia, fetal growth restriction, and diabetes. While numerous experimental studies have focused on establishing the role of endothelial dysfunction in pathophysiology of these gestational complications, their mechanisms remain unknown. Numerous biomarkers of endothelial dysfunction have been proposed, together with the mechanisms by which they relate to individual gestational complications. However, more studies are required to determine clinically relevant markers specific to a gestational complication of interest, as currently most of them present a significant overlap. Although the independent diagnostic value of such markers remains to be insufficient for implementation in standard clinical practice at the moment, inclusion of certain markers in predictive multifactorial models can improve their prognostic value. The future of the research in this field lies in the fine tuning of the clinical markers to be used, as well as identifying possible therapeutic techniques to prevent or reverse endothelial damage.

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Section: Discussionmentioning

confidence: 99%

Endothelial Dysfunction in Pregnancy Complications

et al. 2021

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“…Blood samples from the umbilical cord in placentas from patients with GDM showed elevated glucose and fibrinogen levels. [17] We reported two patients 26 and 24 years old who had increased fibrinogen levels (484.4 and 414.7 mg/dL) associated with decreased blood glucose levels (64 and 63.73 mg/dL). No patient had elevated glucose and fibrinogen levels, although 8 (7.76%) patients had elevated fibrinogen levels and 4 (1.92%) others had elevated blood glucose levels.…”

Section: Discussionmentioning

confidence: 99%

Coagulation tests and blood glucose before vaginal delivery in healthy teenage pregnant women compared with healthy adult pregnant women

Covali¹,

Socolov²,

Socolov³

2019

Medicine

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The aim of this study was to compare the coagulation tests and blood glucose levels between healthy teenage pregnant patients and healthy adult pregnant patients just before vaginal delivery In a prospective study, 208 consecutive patients, 3rd trimester healthy pregnant women, underwent blood tests to determine their glucose levels the day before vaginal delivery. Of the 208 patients, 103 also underwent blood coagulation testing performed on the same day. The median values of the coagulation tests (APTT, prothrombin time, INR, prothrombin activity) and blood glucose were very similar in the healthy pregnant teenagers (32.6; 12.9; 1.02; 97.1; 81) compared with that in the healthy adult pregnant patients (32.45; 13.1; 1.01; 97.5; 81.2). Only the median value for fibrinogen was significantly different in healthy pregnant teenagers (348.9 mg/dL) (interquartile range 21.7) compared with that in healthy adult pregnant patients (359.1 mg/dL) (interquartile range 29.88). Significantly different median blood glucose levels also occurred in the <20; 20–29; 30–39; >40 age groups, but the glucose levels were still within normal limits. Even if there was variability between blood values from one age group to another, the median values for coagulation tests and blood glucose were very close in the healthy teenage pregnant patients compared with the median values of the healthy adult pregnant patients, just before vaginal delivery. With very few exceptions, the values for coagulation tests and blood glucose were within normal limits in all age groups of healthy pregnant patients.

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“…La DMG y el consumo excesivo de sacarosa tienen efectos adversos para la salud de la madre y el hijo. Por su parte, la DMG afecta al hijo ocasionando hiperglicemias durante su etapa intrauterina, así como hiperinsulinemia e hipoglicemia al nacimiento (Lorenzo-Almorós et al, 2019;Szmuilowicz et al, 2019;), alteración en el metabolismo de lípidos, aminoácidos y purinas (Chen et al, 2018), predisposición al aumento del tamaño del tejido adiposo (Logan et al, 2017), ocasionando secreción de citocinas proinflamatorias, obesidad (Szmuilowicz et al, 2019) y síndrome metabólico (Mustad et al, 2020;Kereliuk et al, 2017;López Morales et al, 2016). Se ha documentado la expresión y efectos de citocinas proinflamatorias en la DMG como: interleucina 1 (IL-1), interleucina 6 (IL-6) (Vigil de Gracia y Olmedo, 2017), factor de necrosis tumoral alfa (TNF-α) (Mustad et al, 2020) e interferón gamma (IFN-γ) (Vuong et al, 2017).…”

Section: Introductionunclassified

Efecto inflamatorio en crías de hembras con diabetes mellitus gestacional con consumo elevado de sacarosa

Aguilar-Rodríguez,

Martínez-Carrillo,

Valdés-Ramos

et al. 2023

Rev Agro

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La diabetes mellitus gestacional (DMG) es una enfermedad que se presenta por causas multifactoriales. La alimentación saludable en este periodo es fundamental para conducirlo a un buen desarrollo y conclusión de este, motivo por el cual se debe cuidar la cantidad y calidad de nutrimentos que se consumen. La sacarosa se consume de forma habitual y en ocasiones con exceso. Se ha estudiado su efecto en diversas circunstancias, pero no su efecto en los marcadores inflamatorios de los hijos de madres con este padecimiento. Por lo tanto, el objetivo de este estudio experimental fue evaluar el efecto inflamatorio en las crías de ratonas con DMG con consumo elevado de sacarosa. Se utilizaron 24 ratones hembra de la cepa CD1, divididas en 4 tratamientos (n = 6 por tratamiento): A. Sin DMG, sin sacarosa, B. Sin DMG, con sacarosa, C. Con DMG, sin sacarosa y D. Con DMG, con sacarosa. La inducción de DMG se hizo al sexto día post-apareo, la suplementación con sacarosa se inició al día 12 post-apareo y duró hasta el final de la gestación. Las crías del tratamiento A presentaron un peso corporal mayor (1.74 g) que los otros tres tratamientos. Las crías del grupo D presentaron los valores más elevados de glucosa (106 mg/dL) en comparación con los otros tres tratamientos. En la mayoría de los casos, las crías de los tratamientos con suplementación de sacarosa (B y D) mostraron mayor concentración de citocinas proinflamatorias que su contraparte sin sacarosa. Se demuestra que la presencia de diabetes mellitus gestacional aunado con el consumo excesivo de sacarosa, son factores de riesgo que instauran un estado inflamatorio en el recién nacido.

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Aterosclerosis placentaria y marcadores de disfunción endotelial en neonatos hijos de madres con diabetes gestacional

Cited by 9 publications

References 25 publications

Endothelial Dysfunction in Pregnancy Complications

Endothelial Dysfunction in Pregnancy Complications

Coagulation tests and blood glucose before vaginal delivery in healthy teenage pregnant women compared with healthy adult pregnant women

Efecto inflamatorio en crías de hembras con diabetes mellitus gestacional con consumo elevado de sacarosa

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