ATF7-Dependent Epigenetic Changes Are Required for the Intergenerational Effect of a Paternal Low-Protein Diet

Yoshida, Koshi; Maekawa, Tomoko; Ly, Nhung Hong; Fujita, Shin ichiro; Muratani, Masafumi; Ando, Masahiro; Katou, Yuki; Araki, Hiromitsu; Miura, Fumihito; Shirahige, Katsuhiko; Okada, Mariko; Ito, Takashi; Chatton, Bruno; Ishii, Shunsuke

doi:10.1016/j.molcel.2020.02.028

Cited by 61 publications

(57 citation statements)

References 68 publications

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“…In fact, some authors described that the expression of some sperm small RNAs and tsRNAs rapidly changed in relation to male high-sugar diets [75,76]. The profiles of these RNA were related to sperm quality and embryo viability [77], and may also affect histone modifications and tsRNA biogenesis at the testis level [78]. Therefore, epigenetic components are important affectations to be studied when sperm cells are subjected to an oxidative environment.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Sperm Oxidative Stress Alterations and IVF/ICSI Outcomes: A Systematic Review from Nonhuman Mammals

Ribas-Maynou

Yeste

Salas‐Huetos

2020

Biology

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Achieving high embryo quality following IVF and ICSI procedures is a key factor in increasing fertility outcomes in human infertile couples. While the male factor is known to underlie infertility in about 50% of cases, studies performed in human infertile couples have not been able to define the precise effect of sperm affectations upon embryo development. This lack of consistency is, in most cases, due to the heterogeneity of the results caused by the multiple male and female factors that mask the concrete effect of a given sperm parameter. These biases can be reduced with the use of animal gametes, being a good approach for basic researchers to design more homogeneous studies analyzing the specific consequences of a certain affectation. Herein, we conducted a systematic review (March 2020) that assessed the relationship between sperm oxidative stress alterations and IVF/ICSI outcomes in nonhumans mammals. The review was conducted according to PRISMA guidelines and using the MEDLINE-PubMed and EMBASE databases. Thirty articles were included: 11 performed IVF, 17 conducted ICSI, and two carried out both fertilization methods. Most articles were conducted in mouse (43%), cattle (30%) and pig models (10%). After IVF treatments, 80% of studies observed a negative effect of sperm oxidative stress on fertilization rates, and 100% of studies observed a negative effect on blastocyst rates. After ICSI treatments, a positive relationship of sperm oxidative stress with fertilization rates (75% of studies) and with blastocyst rates (83% of studies) was found. In conclusion, the present systematic review shows that sperm oxidative stress is associated with a significant reduction in fertilization rates and in vitro embryo development.

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Section: Discussionmentioning

confidence: 99%

The Relationship between Sperm Oxidative Stress Alterations and IVF/ICSI Outcomes: A Systematic Review from Nonhuman Mammals

Ribas-Maynou

Yeste

Salas‐Huetos

2020

Biology

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“…These challenging situations in tsRNA research await clarification and resolution. [63,64], epigenetic inheritance [42,[65][66][67][68], and symbiosis [69]. Unlike other canonical sncRNAs such as miRNAs, siRNAs, and piRNAs, which usually function through strict molecular mechanisms by binding to Argonaute family proteins, the mechanisms of action of tsRNAs appear to be more diverse.…”

Section: Evolving Tsrna Functionalitiesmentioning

confidence: 99%

Origins and evolving functionalities of tRNA-derived small RNAs

Chen

Zhang

Shi

et al. 2021

Trends in Biochemical Sciences

122

109

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Transfer RNA (tRNA)-derived small RNAs (tsRNAs) are among the most ancient small RNAs in all domains of life and are generated by the cleavage of tRNAs. Emerging studies have begun to reveal the versatile roles of tsRNAs in fundamental biological processes, including gene silencing, ribosome biogenesis, retrotransposition, and epigenetic inheritance, which are rooted in tsRNA sequence conservation, RNA modifications, and protein-binding abilities. We summarize the mechanisms of tsRNA biogenesis and the impact of RNA modifications, and propose how thinking of tsRNA functionality from an evolutionary perspective urges the expansion of tsRNA research into a wider spectrum, including cross-tissue/cross-species regulation and harnessing of the 'tsRNA code' for precision medicine. On the ancientness of tsRNAs/tRNAsWith the wide application of high-throughput RNA sequencing (RNA-seq), tRNA-derived small RNAs (tsRNAs) (also called tDRs or tRNA-derived fragments, tRFs) are increasingly recognized as an emerging class of functional small noncoding RNAs (sncRNAs) in various fundamental biological and disease conditions [1,2]. tsRNAs have been identified in a wide range of species across all three domains of life, including Archaea, Bacteria, and some unicellular organisms (e.g., Protozoa), where other specialized small RNA pathways, such as miRNAs, siRNAs, and Piwi-interacting RNAs (piRNAs), are lacking [3][4][5][6][7]. These observations have positioned tsRNAs among the most ancient classes of sncRNAs for intra-and intercellular functionality and communication that may pre-date the emergence of more specialized sncRNAs. Highlights tRNA-derived small RNAs (tsRNAs) are present across all three domains of life: Archaea, Bacteria, and Eukarya.

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“…Recently, we found that the transcription factor ATF7 is a key factor for intergenerational inheritance of traits resulting from pLPD in mice (Yoshida et al, 2020). In testicular germ cells (TGCs), ATF7 binds to promoter regions and induces methylation of histone H3 lysine 9 (H3K9me2) via physical interaction with the…”

Section: Introductionmentioning

confidence: 99%