Atg11 Directs Autophagosome Cargoes to the PAS Along Actin Cables

Monastyrska, Iryna; Shintani, Takahiro; Klionsky, Daniel J.; Reggiori, Fulvio

doi:10.4161/auto.2.2.2298

Cited by 25 publications

(20 citation statements)

References 22 publications

(41 reference statements)

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“…Before binding to Atg8, the prApe1-Atg19 complex binds directly to Atg11, which transports the complex to the pre-autophagosomal structure (PAS) through an interaction with the actin cytoskeleton. 43 Atg11 also interacts with Atg9 and the Atg1/ULK complex and thereby serves to scaffold the machinery required for sequestration of the ApeI complex into small, autophagosome-like, Cvt vesicles. 46 Interestingly, increased Atg11 expression facilitates recruitment of Atg8 and Atg9 to the PAS and formation of more Cvt vesicles, suggesting that Atg11 can regulate the rate of selective autophagy.…”

Section: Adaptor Proteinsmentioning

confidence: 99%

The role of ALFY in selective autophagy

2012

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Autophagy, a highly conserved lysosomal degradation pathway, was initially characterized as a bulk degradation system induced in response to starvation. In recent years, autophagy has emerged also as a highly selective pathway, targeting various cargoes such as aggregated proteins and damaged organelles for degradation. The key factors involved in selective autophagy are autophagy receptors and adaptor proteins, which connect the cargo to the core autophagy machinery. In this review, we discuss the current knowledge about the only mammalian adaptor protein identified thus far, autophagy-linked FYVE protein (ALFY). ALFY is a large, scaffolding, multidomain protein implicated in the selective degradation of ubiquitinated protein aggregates by autophagy. We also comment on the possible role of ALFY in the context of disease.

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Section: Adaptor Proteinsmentioning

confidence: 99%

The role of ALFY in selective autophagy

2012

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“…17 In this particular case, Atg11 could be the molecule that provides the binding to the actin cable. 18 Alternatively and as proposed for mitochondria, 13 the Arp2/3 complex could act in a similar way as a motor protein and mediate prApe1 oligomer movement along actin cables ( Fig. 2A).…”

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confidence: 74%

H arp ooning the Cvt complex to the phagophore assembly site

2008

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“…1A). [6][7][8]22 These data indisputably show that Atg9 trafficking is tightly and differentially regulated. Why is Atg9 anterograde transport to the PAS regulated?…”

Section: Atg9 Transport To the Pas: The Cvt And The Bulk Autophagy Modesmentioning

confidence: 88%

“…1A). [6][7][8]22 Very recently, it has been shown that during the Cvt pathway this transport step is also impaired in the absence of Atg23 and the Atg27 transmembrane protein (Fig. 1A).…”

Section: Atg9 Transport To the Pas: The Cvt And The Bulk Autophagy Modesmentioning

confidence: 91%

“…6 The actin cytoskeleton participates in the movement of the Cvt complex in proximity of the vacuole limiting membrane. 8,22 In the absence of Ape1, Atg19, Atg11 and actin filaments, the Atg9 anterograde transport from the cytoplasmic and mitochondrial locations to the PAS is blocked (Fig. 1A).…”

Section: Atg9 Transport To the Pas: The Cvt And The Bulk Autophagy Modesmentioning

confidence: 99%

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