ATG12 is involved in the antiviral immune response in large yellow croaker (Larimichthys crocea)

Wei, Zuyun; Wen, Qiao; Li, Wanru; Yuan, Xiaoqin; Fu, Qiuling; Cui, Zhengwei; Chen, Xinhua

doi:10.1016/j.fsi.2021.10.015

Cited by 8 publications

(3 citation statements)

References 42 publications

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“…Although the regulation of this process remains incompletely understood, it has been found to induce the formation of the autophagosome membrane and type I interferons (IFNs). The process have been shown to play a crucial role in the antiviral immunity of Larimichthys crocea (Richardson) (Wei et al, 2021), Epinephelus coioides (Hamilton) (Li et al, 2019), and (Chu et al, 2019), shedding light on the potential involvement of ATG12 in antiviral immunity by stimulating both autophagy and type I interferon response. Consequently, it is hypothesized that ATG12 may eliminate intracellular pathogens and damaged celles within V. fijiensis by regulating autophagy homeostasis, which have contributed to its adaptation of harsh deep-sea environments.…”

Section: Key Genes Implicated In Deepsea Adaptationmentioning

confidence: 99%

Comparative omics analysis of a deep-sea barnacle species (Cirripedia, Scalpellomorpha) and shallow-water barnacle species provides insights into deep-sea adaptation

Mao,

Shao,

Cai

et al. 2024

Front. Mar. Sci.

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Barnacles have demonstrated adaptability to a range of habitats, spanning from shallow water to the deep sea. Given the harsh conditions present in hydrothermal vents, hydrothermal vent barnacles serve as the model organism for investigating the interplay between evolution and adaptability. In order to gain insights into barnacle adaptive characteristics, particularly within hydrothermal vents, we conducted a comprehensive analysis of the mitogenomes and transcriptome in a deep-sea barnacle (Vulcanolepas fijiensis), in comparison to its shallow-water related species. The mitogenomes with the same genetic skews and the non-synonymous/synonymous mutation ratios (Ka/Ks) of the mitogenomes indicate that the protein-coding genes (COIII, ND2, and ND6) of V. fijiensis are under positive selection. Meanwhile, the functional annotation shows that distinctly positive selected orthologs in V. fijiensis are predominately related to neural signal transduction, immunity, antiapoptotic, and energy metabolism. These results indicate that the mitogenomes and key genes found in transcriptomic analysis are under high-temperature and high-pressure conditions, and which may contribute V. fijiensis to have evolved to adapt to the extreme hydrothermal vent environments. The findings shed light on the mitogenome and transcriptome of V. fijiensis, which lays a foundation for the in-depth understanding of the adaptation mechanism of sessile invertebrates to the deep-sea environment.

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Section: Key Genes Implicated In Deepsea Adaptationmentioning

confidence: 99%

Comparative omics analysis of a deep-sea barnacle species (Cirripedia, Scalpellomorpha) and shallow-water barnacle species provides insights into deep-sea adaptation

Mao,

Shao,

Cai

et al. 2024

Front. Mar. Sci.

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“…In addition, overexpressing ATG12 of large yellow croaker (Larimichthys crocea) could induce the occurrence of autophagy and increase the expression levels of large yellow croaker type I interferons, IFN regulatory factors and IFN-stimulated genes. 137 Since autophagy has been found to be beneficial to SVCV replication, 36 the Others may be synergistic. That is, some piscine ATG proteins have consistent effects on specific virus replication considering their autophagic roles and regulation for innate immune response.…”

Section: Crosstalk Between Autophagy and Immune Response During Aquat...mentioning

confidence: 99%

“…It has been demonstrated that autophagy inhibited SGIV replication by rapamycin and wortmannin treatment, 119 which suggests that overexpression of grouper ATG5, ATG12 or ATG16L1 dominantly affected SGIV replication through down‐regulating innate immunity. In addition, overexpressing ATG12 of large yellow croaker ( Larimichthys crocea ) could induce the occurrence of autophagy and increase the expression levels of large yellow croaker type I interferons, IFN regulatory factors and IFN‐stimulated genes 137 . Since autophagy has been found to be beneficial to SVCV replication, 36 the inhibition of ATG12 on SVCV replication in a large part depends on that it could positively regulate innate immunity.…”

Section: The Roles Of Autophagy In Aquatic Animal Virus Infectionmentioning

confidence: 99%

Autophagy regulation of virus infection in aquatic animals

Zhang

Zhao

et al. 2023

Reviews in Aquaculture

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Autophagy is a conserved intracellular degradation process that is required to maintain host homeostasis and cope with invading pathogens. Over the past few decades, studies on mammals have greatly increased our understanding of the relationship between autophagy and virus infection. Autophagy may convey the invader to lysosomes to degrade or activate the host immune response against virus replication. However, many viruses have developed some strategies that evade the degradative nature of autophagy or hijack this pathway for their gain. It follows that autophagy during viral infection is a double‐edged sword. In contrast to mammals, the review on autophagy modulated by the aquatic animal virus is limited. Here, after a brief description of the main information about autophagy, we highlight current progress on the interplays between autophagy and virus infection in aquatic animals, including the phenomenon of autophagy upon virus infection, the effect of modulating autophagy on virus replication, and the crosstalk between autophagy and immune response during virus infection. This review will help us better understand the pathogenic mechanism of aquatic animal viruses and develop proper antiviral countermeasures aimed at modulating autophagy.

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A new embryonic cell line YCE1 from large yellow croaker (Larimichthys crocea) and its susceptibility to large yellow croaker iridovirus

et al. 2023

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ATG12 is involved in the antiviral immune response in large yellow croaker (Larimichthys crocea)

Cited by 8 publications

References 42 publications

Comparative omics analysis of a deep-sea barnacle species (Cirripedia, Scalpellomorpha) and shallow-water barnacle species provides insights into deep-sea adaptation

Comparative omics analysis of a deep-sea barnacle species (Cirripedia, Scalpellomorpha) and shallow-water barnacle species provides insights into deep-sea adaptation

Autophagy regulation of virus infection in aquatic animals

A new embryonic cell line YCE1 from large yellow croaker (Larimichthys crocea) and its susceptibility to large yellow croaker iridovirus

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