2023
DOI: 10.1073/pnas.2217451120
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ATG5 selectively engages virus-tethered BST2/tetherin in an LC3C-associated pathway

Abstract: Bone marrow stromal antigen 2 (BST2)/tetherin is a restriction factor that reduces HIV-1 dissemination by tethering virus at the cell surface. BST2 also acts as a sensor of HIV-1 budding, establishing a cellular antiviral state. The HIV-1 Vpu protein antagonizes BST2 antiviral functions via multiple mechanisms, including the subversion of an LC3C-associated pathway, a key cell intrinsic antimicrobial mechanism. Here, we describe the first step of this viral-induced LC3C-associated process. This process is init… Show more

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Cited by 7 publications
(8 citation statements)
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“…We, therefore, propose that the interaction of ATG5, BST2, and HBx may also affect BST2 degradation to promote HBV replication. In addition, we found HBx did not affect ATG5‐BST2 interaction, which was different from the case that ATG5 preferentially target virus‐tethered BST2 in HIV infection 24 . However, the specific mechanisms need to be further studied.…”
Section: Discussioncontrasting
confidence: 66%
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“…We, therefore, propose that the interaction of ATG5, BST2, and HBx may also affect BST2 degradation to promote HBV replication. In addition, we found HBx did not affect ATG5‐BST2 interaction, which was different from the case that ATG5 preferentially target virus‐tethered BST2 in HIV infection 24 . However, the specific mechanisms need to be further studied.…”
Section: Discussioncontrasting
confidence: 66%
“…BST2 has been reported to inhibit the release of enveloped viruses such as HBV and HIV 23,24 . We, therefore, investigated the regulation of ATG5 and BST2 on HBV replication in HepAD38 with inducible HBV replication and HBV‐infected NTCP‐HepG2 cells 26,27 .…”
Section: Resultsmentioning
confidence: 99%
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“…It is likely that HIV-1 targets non-canonical autophagy as well, such as LC3-associated phagocytosis (LAP) [ 4 , 127 ]. For example, Vpu recruits LC3C at the budding site to remove Tetherin by a non-canonical autophagy reminiscent of LAP [ 103 , 161 ]. However, future research is needed to understand and clearly dissect the roles of canonical and non-canonical autophagy in HIV-1 replication.…”
Section: Discussionmentioning
confidence: 99%