ATG7-mediated autophagy involves in miR-138-5p regulated self-renewal and invasion of lung cancer stem-like cells derived from A549 cells

Zhou, Qian; Cui, Fenghe; Lei, Chenggang; Ma, Shengwei; Huang, Jiang-Ping; Wang, Xianghui; Qian, Haiyun; Zhang, Deming; Yang, Yalun

doi:10.1097/cad.0000000000000979

Cited by 16 publications

(9 citation statements)

References 28 publications

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“…This form of autophagy promotes metastasis, allowing the cancer to spread and wreak havoc throughout the body. This was demonstrated in pancreatic, colorectal, and lung cancers [ 5 , 6 , 52 ].…”

Section: Autophagymentioning

confidence: 99%

Autophagy Regulation on Cancer Stem Cell Maintenance, Metastasis, and Therapy Resistance

Wang

Golino

Xie

2022

Cancers

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Cancer stem cells (CSCs) are a subset of the tumor population that play critical roles in tumorigenicity, metastasis, and relapse. A key feature of CSCs is their resistance to numerous therapeutic strategies which include chemotherapy, radiation, and immune checkpoint inhibitors. In recent years, there is a growing body of literature that suggests a link between CSC maintenance and autophagy, a mechanism to recycle intracellular components during moments of environmental stress, especially since CSCs thrive in a tumor microenvironment that is plagued with hypoxia, acidosis, and lack of nutrients. Autophagy activation has been shown to aid in the upkeep of a stemness state along with bolstering resistance to cancer treatment. However, recent studies have also suggested that autophagy is a double-edged sword with anti-tumorigenic properties under certain circumstances. This review summarizes and integrates what has been published in the literature in terms of what role autophagy plays in stemness maintenance of CSCs and suggests that there is a more complex interplay between autophagy and apoptosis which involves multiple pathways of regulation. Future cancer therapy strategies are needed to eradicate this resistant subset of the cell population through autophagy regulation.

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Section: Autophagymentioning

confidence: 99%

Autophagy Regulation on Cancer Stem Cell Maintenance, Metastasis, and Therapy Resistance

Wang

Golino

Xie

2022

Cancers

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“…It has been revealed that Lung CSCs can degrade p53 through the autophagy pathway, thereby enhancing Zeb1 expression and regulating stemness, suggesting that the autophagy-p53-Zeb1 axis regulates the self-renewal ability of CSCs ( 61 ). Moreover, in lung cancer stem cells, miR-138-5p mimic can inhibit ATG7-dependent regulation of autophagy and self-renewal ( 62 ).…”

Section: The Mechanism Of Autophagy Affecting Nsclc Progressionmentioning

confidence: 99%

Recent Advances of Autophagy in Non-Small Cell Lung Cancer: From Basic Mechanisms to Clinical Application

Guo

Luo

et al. 2022

Front. Oncol.

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Lung cancer is characterized by the most common oncological disease and leading cause of cancer death worldwide, of which a group of subtypes known as non-small cell lung cancer (NSCLC) accounts for approximately 85%. In the past few decades, important progression in the therapies of NSCLC has enhanced our understanding of the biology and progression mechanisms of tumor. The application of immunotherapy and small molecule tyrosine kinase inhibitors has brought significant clinical benefits in certain patients. However, early metastasis and the emergence of resistance to antitumor therapy have resulted in the relatively low overall cure and survival rates for NSCLC. Autophagy is a conserved process that allows cells to recycle unused or damaged organelles and cellular components. It has been reported to be related to the progression of NSCLC and resistance to targeted therapy and cytotoxic chemotherapy. Therefore, autophagy is considered as a potential therapeutic target for NSCLC. Mounting results have been reported about the combination of tyrosine kinase inhibitors and inhibitors of autophagy in models of NSCLC. This review aims to provide a comprehensive review on the roles of autophagy in NSCLC, focusing on related clinical data of agents that regulate autophagy in NSCLC. Furthermore, this study will provide a theoretical basis for further improvement of autophagy-based cancer therapy.

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“…Noteworthy, EGCG (0–40 μM) reduces mRNA and protein levels of CLOCK to impair CSCs features and suppress self-renewal capacity of CSCs in lung tumor therapy [ 163 ]. The miRNAs are considered as important modulators of CSCs in cancer [ 164 , 165 , 166 , 167 ]. The expression level of hsa-miRNA-485-5p undergoes down-regulation in serum of lung tumor patients, showing tumor-suppressor role of this miRNA.…”

Section: Dietary Agents and Cancer Stem Cellsmentioning

confidence: 99%

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

Paskeh

Asadi²,

Zabolian

et al. 2021

IJMS

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As a multifactorial disease, treatment of cancer depends on understanding unique mechanisms involved in its progression. The cancer stem cells (CSCs) are responsible for tumor stemness and by enhancing colony formation, proliferation as well as metastasis, and these cells can also mediate resistance to therapy. Furthermore, the presence of CSCs leads to cancer recurrence and therefore their complete eradication can have immense therapeutic benefits. The present review focuses on targeting CSCs by natural products in cancer therapy. The growth and colony formation capacities of CSCs have been reported can be attenuated by the dietary agents. These compounds can induce apoptosis in CSCs and reduce tumor migration and invasion via EMT inhibition. A variety of molecular pathways including STAT3, Wnt/β-catenin, Sonic Hedgehog, Gli1 and NF-κB undergo down-regulation by dietary agents in suppressing CSC features. Upon exposure to natural agents, a significant decrease occurs in levels of CSC markers including CD44, CD133, ALDH1, Oct4 and Nanog to impair cancer stemness. Furthermore, CSC suppression by dietary agents can enhance sensitivity of tumors to chemotherapy and radiotherapy. In addition to in vitro studies, as well as experiments on the different preclinical models have shown capacity of natural products in suppressing cancer stemness. Furthermore, use of nanostructures for improving therapeutic impact of dietary agents is recommended to rapidly translate preclinical findings for clinical use.

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ATG7-mediated autophagy involves in miR-138-5p regulated self-renewal and invasion of lung cancer stem-like cells derived from A549 cells

Cited by 16 publications

References 28 publications

Autophagy Regulation on Cancer Stem Cell Maintenance, Metastasis, and Therapy Resistance

Autophagy Regulation on Cancer Stem Cell Maintenance, Metastasis, and Therapy Resistance

Recent Advances of Autophagy in Non-Small Cell Lung Cancer: From Basic Mechanisms to Clinical Application

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

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