Atherogenic index of plasma is a novel and strong predictor associated with fatty liver: a cross-sectional study in the Chinese Han population

Abstract

Background Atherogenic index of plasma (AIP) has been reported to be an important predictor for coronary artery disease and obesity. However, few studies has yet systematically evaluated the association between AIP and Fatty Liver (FL) and its advantage in FL prediction compared with BMI, waist, SBP, DBP, BG, ALT and AST. Methods A total of 7838 participants aged from 19 to 93 years were included in this study. Height, weight, waist, SBP, DBP, BG, ALT and AST were measured. Difference analyses, odds ratio calculation, logistic and predictive analyses were used to evaluate the association and discrimination ability between AIP, BMI, waist, SBP, DBP, BG, ALT, AST and FL. Results Compared with non-FL, AIP in FL people showed a significant increase. Subjects in the higher quartiles of AIP had a significantly increased risk of fatty liver compared with those in the lowest quartile (P < 0.01) after adjustment of gender and age. ORs were grown faster in female and youth group. AIP contributed most in the logistic eq. (B = 2.64, P < 0.01) and showed high ability in risk prediction for FL (AUC = 0.810, P < 0.01). Conclusions AIP might be a novel and strong predictor associated with FL in Chinese Han population. Higher AIP level was positively and strongly associated with FL.

WHtR may be a Better and Stronger Indictor for Fatty Liver: A Population-Based Cross-sectional Comparison Study of Anthropometric and Metabolic Indices for Identification Fatty Liver in China

“…As expected, several anthropometric or metabolic indices such as skeletal muscle mass [16], atherogenic index [17,18], Body Mass Index (BMI) [19], the ratio of Triglyceride (TG) to High-Density Lipoprotein cholesterol [20], visceral adipose tissue [21], Total cholesterol (TC) to High-Density Lipoprotein cholesterol ratio [22] and Triglyceride Glucose (TyG) [23,24], as well as blood pressure [25] had been reported to be associated with FL in both cross-sectional and cohort studies. However, most existing studies mainly focused on only one or two indices, which might have limitations for predicting FL considering the high complexity of the pathogenesis of FL.…”

“…AVI is used to assess general volume, and it has been highly associated with dysfunction of glucose metabolism [37]. Researches found that there were concordances between increased AIP and the incidence of FL [17,18]. TyG are often used to explore the relationship between insulin resistance and excessive visceral fat accumulation [38,39].…”

Inverse Association of Serum Fibroblast Growth Factor 19 and Atherogenic Index of Plasma in Type 2 Diabetic Patients

“…Simultaneously, AIP was independently correlated with CHD in males but not in females [30]. Similarly, Gaojun Cai et al found that in the Han Chinese population, AIP was a predictor for the incidence of CAD [31]. In a study of 315 Chinese patients with suspected or established CAD, the serum FGF19 level was an independent predictor of the Gensini score, which represents the presence and severity of CAD [11].…”

Changes in metabolic parameters in psoriatic patients treated with secukinumab

“…On the other hand, AIP is a useful tool to evaluate the risk of cardiovascular diseases. 35 AIP has been associated with heart failure, obesity and non-alcoholic fatty liver disease, 36 – 38 all of which belong to important comorbidities of psoriasis. One study on type 1 diabetes mellitus found an association between triglyceride-to-HDL ratio and hs-CRP level, and they hypothesize that elevated abnormal lipid profile would prompt the formation of foam cells in the arterial wall and increase the inflammatory activity.…”