Atherogenic Risk Factors among Young Indian Adults with Epilepsy on Treatment with Phenytoin: Need for Novel Therapeutic Strategies

A, Sangeetha; Bobby, Zachariah; Wadwekar, Vaibhav; Yadav, Nisha

doi:10.4103/0028-3886.325371

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…A meta‐analysis of 16 case‐control studies (comprised 1918 individuals) found that the CRP blood levels “were significantly increased in epileptic patients compared to healthy controls, indicating a significant association between inflammation and epilepsy.” 71 Subsequent individual studies have confirmed this 72–75,111 …”

Section: Measurement Of Inflammation—what To Measure?mentioning

confidence: 90%

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Systemic inflammation as a biomarker of seizure propensity and a target for treatment to reduce seizure propensity

et al. 2023

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People with diabetes can wear a device that measures blood glucose and delivers just the amount of insulin needed to return the glucose level to within bounds.Currently, people with epilepsy do not have access to an equivalent wearable device that measures a systemic indicator of an impending seizure and delivers a rapidly acting medication or other intervention (e.g., an electrical stimulus) to terminate or prevent a seizure. Given that seizure susceptibility is reliably increased in systemic inflammatory states, we propose a novel closed-loop device where release of a fast-acting therapy is governed by sensors that quantify the magnitude of systemic inflammation. Here, we review the evidence that patients with epilepsy have raised levels of systemic indicators of inflammation than controls, and that some anti-inflammatory drugs have reduced seizure occurrence in animals and humans. We then consider the options of what might be incorporated into a responsive anti-seizure system.

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Section: Measurement Of Inflammation—what To Measure?mentioning

confidence: 90%

“…Almost all the reports documenting circulating indicators of inflammation in people with epilepsy provide measurements after a recent or remote seizure. Indeed, ongoing systemic inflammation (elevated CXCL8 [IL‐8] concentrations) has been documented in adults a week after the last overt seizure, 75 and even months later 92 …”

Section: Timingmentioning

confidence: 99%