Atherogenic Risk Factors and Hearing Thresholds

Frederiksen, Thomas Winther; Ramlau‐Hansen, Cecilia Høst; Stokholm, Zara Ann; Grynderup, Matias Brødsgaard; Hansen, Åse Marie; Lund, Søren Peter; Vestergaard, Jesper Medom; Kristiansen, Jesper; Bonde, Jens Peter; Kolstad, Henrik Albert

doi:10.1159/000365439

Cited by 16 publications

(17 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to other studies, we also found that compared with the control group, the TC/HDL ratio, apo B/apo AI ratio and ATH index in SSNHL were higher [10], suggesting the possibility of atherosclerosis in SSNHL patients [21,23]. Apo B/apo AI ratio and ATH index were also found to be favorable predictors of plasma atherosclerosis [15,24].…”

Section: Resultssupporting

confidence: 88%

Association of Dyslipidemia With Sudden Sensorineural Hearing Loss: A Retrospective Study

Li¹,

Xu²,

Yang³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Blood lipid levels have been widely studied in patients with sudden sensorineural hearing loss (SSNHL), but it has been unclear whether dyslipidemia associates with SSNHL. Whether there is a simple and feasible blood lipid index to predict the onset of SSNHL remains to be found.Methods: This study reviewed 100 SSNHL patients and 100 healthy subjects who received relevant clinical examination in our hospital from June 1, 2015 to June 1, 2019. The demographic, clinical characteristics, lipid levels and lipid metabolism indexes of the two groups were compared.Results: In this study, 100 patients (64 men [64%]; 36 women [36%]; mean [SD] age, 38.47 [14.36] years) were included in the SSNHL group, and 100 healthy people(60 men [60%]; 40 women [40%]; mean [SD] age, 36.52 [9.86] years) served as the control group. No significant differences between the SSNHL group and the control group in age, sex, BMI, smoking habits and alcohol drinking patterns were observed. Meanwhile, it can be seen the mean (SD) concentrations of total cholesterol (TC) (194.59 [38.22] vs 176.83 [23.55] mg/dL; MD, 17.76 mg/dL; 95% CI, 26.64-46.72 mg/dL), the mean (SD) concentrations of low density lipoprotein cholesterol (LDL-C) (116.99 [33.59] vs 96.91 [22.01] mg/dL; MD, 20.08 mg/dL; 95% CI, 32.43-48.26 mg/dL) and apolipoprotein (apo) B (89.82 [21.38] vs 81.16 [16.17] mg/dL; MD, 8.66 mg/dL; 95% CI, 12.03-23.21 mg/dL) were significantly higher than the control group. In addition, it was also observed that the median [IQR] concentrations of high density lipoprotein cholesterol (HDL-C) (1.51 [1.33-1.76] vs 1.56 [1.40-1.84] mg/dL) and the median [IQR] concentrations of apolipoprotein (apo) AI (118.50 [103.00-141.25] vs 133.00 [115.25-1.52.75] mg/dL) were lower than those in the control group. In terms of lipid metabolism indexes, the median [IQR] value of TC/HDL-C (3.31 [2.68-3.85] vs 2.72 [2.42-3.37]), the mean (SD) value of apo B/apo AI (0.76 [0.26] vs 0.63 [0.18]; MD, 0.13; 95% CI, 0.20-0.32) and the median [IQR] value of atherogenic index (ATH index) (1.61 [0.97-2.50] vs 1.01 [0.73-1.75]) were significantly higher than the control group, while the mean (SD) value of atherogenic index of plasma (AIP) (-0.24 [0.28] vs -0.25 [0.21]; MD, 0.01; 95% CI, -0.06-0.08) showed no difference between the two groups.Conclusions: There were significant differences in blood lipid levels and lipid metabolism between the SSNHL group and the control group. LDL-C, apo AI and apo B were important independent predictors of SSNHL.

show abstract

Section: Resultssupporting

confidence: 88%

Association of Dyslipidemia With Sudden Sensorineural Hearing Loss: A Retrospective Study

Li¹,

Xu²,

Yang³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…The current results are significant across all PTA thresholds in the overall groups. This contrasts with other studies who have found associations between cardiovascular disease and its risk factors to low‐frequency hearing loss . The proposed mechanism for these results from prior studies suggest microvascular disease leading to ischemic degeneration of the stria vascularis, particularly at the more distal apical parts of the cochlea, causing low‐frequency hearing loss.…”

Section: Discussioncontrasting

confidence: 81%

“…This contrasts with other studies who have found associations between cardiovascular disease and its risk factors to low-frequency hearing loss. 7,10,11,26,27 The proposed mechanism for these results from prior studies suggest microvascular disease leading to ischemic degeneration of the stria vascularis, particularly at the more distal apical parts of the cochlea, causing low-frequency hearing loss. The findings in our study may be due to the differences in the study cohorts and demographics.…”

Section: Discussionmentioning

confidence: 85%

Relationship of stroke risk and hearing loss in African Americans: The Jackson Heart Study

et al. 2017

View full text Add to dashboard Cite

show abstract

“…This is in accordance with the hypotheses that cardiovascular risk factors affect the whole frequency range. Stronger associations with low-frequency hearing thresholds are found previously for cardiovascular risk factors (Frederiksen et al, 2014;Friedland et al, 2009) and for cardiovascular disease (Gates et al, 1993;Friedland et al, 2009).…”

Section: Frequency Specific Effectsmentioning

confidence: 55%