Atheroprotective role of high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P)

Potì, Francesco; Simoni, Manuela; Nofer, Jerzy Roch

doi:10.1093/cvr/cvu136

Cited by 95 publications

(98 citation statements)

References 107 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These data provide direct evidence to support the previously hypothesized physical interactions between the SR-BI and S1PR1 receptor proteins (20,22,48,49). However, additional studies will be required to determine if incubation of other cell types with HDL-S1P stimulates the interaction between these two receptors and whether different interaction rates between SR-BI and the other S1P receptors (S1PR2 and S1PR3) may influence HDL-mediated S1PR signaling and function.…”

Section: Discussionsupporting

confidence: 67%

S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization

Lee

Appleton

El‐Shewy

et al. 2017

Journal of Lipid Research

View full text Add to dashboard Cite

Journal of Lipid Research Volume 58, 2017325 interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization. J. Lipid Res. 2017. 58: 325-338.Supplementary key words high density lipoprotein • sphingosine 1-phosphate • protein-fragment complementation assay • scavenger receptor BI • S1P receptorsThe reverse transport of cholesterol from the periphery to the liver is often considered as the hallmark antiatherogenic function of HDL. SR-BI, the first molecularly characterized HDL receptor that plays a critical role in this metabolism, is abundantly expressed in several types of cells and tissue types, including the liver parenchyma, adrenal cortical cells, platelets, endothelial cells, smooth muscle cells, and macrophages. SR-BI facilitates the selective uptake of HDL cholesterol by cells, primarily in the form of cholesteryl esters. SR-BI also mediates the bidirectional flux of unesterified cholesterol and phospholipids between HDL and cells, which leads to an increase in cellular cholesterol mass and alters cholesterol distribution in plasma membrane domains (1-4).Numerous studies have detailed the various signaling pathways generated by the interaction of HDL with cell surface receptors that have been shown to induce myriad Abstract HDL normally transports about 50-70% of plasma sphingosine 1-phosphate (S1P), and the S1P in HDL reportedly mediates several HDL-associated biological effects and signaling pathways. The HDL receptor, SR-BI, as well as the cell surface receptors for S1P (S1PRs) may be involved partially and/or completely in these HDL-induced processes. Here we investigate the nature of the HDLstimulated interaction between the HDL receptor, SR-BI, and S1PR1 using a protein-fragment complementation assay and confocal microscopy. In both primary rat aortic vascular smooth muscle cells and HEK293 cells, the S1P content in HDL particles increased intracellular calcium concentration, which was mediated by S1PR1. Mechanistic studies performed in HEK293 cells showed that incubation of cells with HDL led to an increase in the physical interaction between the SR-BI and S1PR1 receptors that mainly occurred on the plasma membrane. Model recombinant HDL (rHDL) particles formed in vitro with S1P incorporated into the particle initiated the internalization of S1PR1, whereas rHDL without supplemented S1P did not, suggesting that S1P transported in HDL can selectively activate S1PR1. In conclusion, these data suggest that S1P in HDL stimulates the transient interaction between SR-BI and S1PRs that can activate S1PRs and induce an elevation in intracellular calcium concentration.-Lee,

show abstract

Section: Discussionsupporting

confidence: 67%

S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization

Lee

Appleton

El‐Shewy

et al. 2017

Journal of Lipid Research

View full text Add to dashboard Cite

show abstract

“…It is difficult to explain a reason of the discrepancies. The present as well as Argraves et al [13] data seem to be logical in the light of the anti-atherogenic properties of S1P showed in in vitro studies [12]. Those data suggest that reduction in S1P plasma level could accelerate development of atherosclerosis.…”

Section: Discussionsupporting

confidence: 67%

“…Sphingosine-1-phosphate was shown, in experimental studies, to exert complex athero-protective action [12]. However, the data on the plasma level of S1P in atherosclerosis are not uniform.…”

Section: Introductionmentioning

confidence: 99%

Blood Bioactive Sphingolipids and Activity of Acid Sphingomyelinase in Patients with Multivessel Coronary Artery Disease

Knapp¹,

Lisowska²

2016

J Clin Exp Cardiolog

View full text Add to dashboard Cite

Aim: Ceramide is claimed to participate in development of atherosclerosis. Another bioactive sphingolipid, namely sphingosine-1-phosphate has anti-atherogenic properties. The aim of the present study was to examine the level of ceramide, sphingosine-1-phosphate, sphinganine-1-phosphate, sphingosine and sphinganine in plasma, erythrocytes and platelets of patients with multivessel coronary artery disease. Material and methods:The group of patients consisted of 36 people of both sexes with multivessel coronary artery disease recommended to coronary artery by-pass grafting. The control group consisted of 20 age-matched subjects without symptoms of the disease. The blood samples were collected and fractionated in plasma, erythrocytes and platelets. The levels of the above listed sphingolipids were determined by means of high performance liquid chromatography. The activity of acidic secretory sphingomyelinase in plasma was determined using 14C-sphingomyelin. Results:It was shown in the group of patients that the plasma levels of sphingosine-1-phosphate and sphinganine-1-phosphate were reduced whereas the levels of other sphingolipids did not differ from the respective values in the control group. The plasma activity of acidic secretory sphingomyelinase was elevated in the group of patients. The levels of the examined sphingolipids in erythrocytes were similar in both groups. In platelets, the level of sphingosine and sphinganine in the group of patients was higher than in the control group. The plasma ceramide/ sphingosine-1-phosphate ratio is elevated by 54% in the group of patients. Conclusion:The results obtained indicate that metabolism of ceratain bioactive sphingolipids in plasma, and platelets in patients with multivessel coronary artery disease are changed as compared to the control group.

show abstract

“…LPA, lysophosphatidic acid; PA, phosphatidic acid; PLA, phospholipase A; PLD, phospholipase D; LPP, lipid phosphate phosphatase; PIP 2 , phosphatidylinositol 4,5-bisphosphate; DAG, diacyl glycerol; AC, adenylyl cyclase; PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase; PLC, phospholipase C; IP 3 , inositol 1,4,5-trisphosphate; ROCK, Rho-associated protein kinase; MLCK, myosin light chain kinase; MEK, mitogen-activated protein kinase kinase; ERK, extracellularsignal-regulated kinases; PKC, protein kinase C; PPARg, peroxisome proliferator-activated receptor gamma; HDAC, histone deacetylase. 3,15,18,21,23,24,[27][28][29]32,71,73,112,116,[118][119][120][121][122][123][124] Color images available online at www.liebertpub.com/teb stresses by regulating Ca 2 + transients. 53 Micromolar levels of LPA may induce a vasoconstrictive response 54 in medial SMCs under high shear stresses, but lower doses cause endothelium-dependent vasodilation via endothelial nitric oxide synthase and phospholipase activity.…”

Section: Figmentioning

confidence: 99%

Lysophosphatidic Acid and Sphingosine-1-Phosphate: A Concise Review of Biological Function and Applications for Tissue Engineering

Binder

Williams

Silva

et al. 2015

Tissue Engineering Part B: Reviews

View full text Add to dashboard Cite

The presentation and controlled release of bioactive signals to direct cellular growth and differentiation represents a widely used strategy in tissue engineering. Historically, work in this field has primarily focused on the delivery of large cytokines and growth factors, which can be costly to manufacture and difficult to deliver in a sustained manner. There has been a marked increase over the past decade in the pursuit of lipid mediators due to their wide range of effects over multiple cell types, low cost, and ease of scale-up. Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are two bioactive lysophospholipids (LPLs) that have gained attention for use as pharmacological agents in tissue engineering applications. While these lipids can have similar effects on cellular response, they possess distinct chemical backbones, mechanisms of synthesis and degradation, and signaling pathways using a discrete set of G-protein-coupled receptors (GPCRs). LPA and S1P predominantly act extracellularly on their GPCRs and can directly regulate cell survival, differentiation, cytokine secretion, proliferation, and migration-each of the important functions that must be considered in regenerative medicine. In addition to these potent physiological functions, these LPLs play pivotal roles in a number of pathophysiological processes. To capitalize on the promise of these molecules in tissue engineering, these lipids have been incorporated into biomaterials for in vivo delivery. Here, we survey the effects of LPA and S1P on both cellular-and tissue-level phenotypes, with an eye toward regulating stem/progenitor cell growth and differentiation. In particular, we examine work that has translational applications for cell-based tissue engineering strategies in promoting cell survival, bone and cartilage engineering, and therapeutic angiogenesis.

show abstract

Atheroprotective role of high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P)

Cited by 95 publications

References 107 publications

S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization

S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization

Blood Bioactive Sphingolipids and Activity of Acid Sphingomyelinase in Patients with Multivessel Coronary Artery Disease

Lysophosphatidic Acid and Sphingosine-1-Phosphate: A Concise Review of Biological Function and Applications for Tissue Engineering

Contact Info

Product

Resources

About